The protective role of crocin in tartrazine induced nephrotoxicity in Wistar rats

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dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorGul, Mehmet
dc.contributor.authorAltinoz, Eyup
dc.contributor.authorZayman, Emrah
dc.contributor.authorAksungur, Zeynep
dc.contributor.authorBag, Harika Gozukara
dc.date.accessioned2024-09-29T15:55:04Z
dc.date.available2024-09-29T15:55:04Z
dc.date.issued2017
dc.departmentKarabük Üniversitesien_US
dc.description.abstractThe present study was conducted to investigate the changes in rat kidney tissues after administration of tartrazine (T) and crocine (Cr). The latter was applied for its protective properties. The present study was conducted with the approval of Inonu University, Faculty of Medicine, Experimental Animals Ethics Committee. Forty rats were randomly divided into 4 equal groups (Control, T, Cr, T + Cr). At the end of the experiment, the rats were decapitated. Biochemical and histopathological studies were conducted on excised rat kidney tissues. It was determined that there was a significant increase in MDA, TOS, SOD, CAT, Bun, Creatinine levels in tartrazine administered rat kidney tissues for 21 days, while GSH and TAS levels decreased (P <= 0.05) when compared to all other groups. On the other hand, it was identified that Cr administration statistically significantly increased GSH and TAS levels in rat kidney tissues when compared to all other groups and decreased MDA and TOS levels to control group levels (P < 0.05). T group kidney sections exhibited different degrees of collapse in the glomeruli. In most sections, different levels of inflammatory cell infiltration and vascular and capillary congestion were detected in peritubular interstitial tissue. It was determined that T leads to adverse effects on rat kidney tissues. Administration of Cr + T prevented T induced nephrotoxicity. Thus, it was concluded that Cr could be utilized as a new type of anti-tartrazine toxicity agent.en_US
dc.identifier.doi10.1016/j.biopha.2017.11.150
dc.identifier.endpage935en_US
dc.identifier.issn0753-3322
dc.identifier.issn1950-6007
dc.identifier.pmid29217164en_US
dc.identifier.scopus2-s2.0-85036645707en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage930en_US
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2017.11.150
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4437
dc.identifier.volume96en_US
dc.identifier.wosWOS:000418502100111en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofBiomedicine & Pharmacotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTartrazineen_US
dc.subjectCrocinen_US
dc.subjectKidneyen_US
dc.subjectOxidative stressen_US
dc.subjectNephrotoxicityen_US
dc.titleThe protective role of crocin in tartrazine induced nephrotoxicity in Wistar ratsen_US
dc.typeArticleen_US

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