Decreased serum profile of the interleukin-36a in polycystic ovary syndrome

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dc.authorideroglu, semra/0000-0002-9959-9433
dc.contributor.authorEroglu, Semra
dc.contributor.authorCakmakliogullari, Elcin Kal
dc.date.accessioned2024-09-29T16:00:49Z
dc.date.available2024-09-29T16:00:49Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to determine the serum adiponectin and interleukin-36 alpha (IL36a) levels in polycystic ovary syndrome (PCOS), and their relationship with obesity. Materials and methods: This observatory study included 80 PCOS patients and 58 controls. The clinical, biochemical, and hormonal parameters, and serum adiponectin and IL-36a levels of the patients were evaluated. Results: The serum IL-36a levels of the PCOS patients were significantly lower when compared to the control group, despite a similar mean body mass index (BMI) (P = 0.000). The adiponectin levels were significantly lower in the obese PCOS group when compared to the obese control group (P = 0.03). The plasma IL-36a level was positively correlated with adiponectin level, but negatively correlated with the serum LH level (P = 0.000 and P = 0.004, respectively). Using receiver operating characteristic analysis, the cut-off value of IL-36a was calculated as 0.815 for PCOS. In the multiple binary logistic regression analysis, IL-36a (OR [95% CI] 0.432 [0.303, 0.616], P < 0.001) and adiponectin (OR [95% CI] 1.044 [1.005, 1.084], P = 0.028) were determined to be significantly associated with PCOS. Conclusion: A reduced IL-36a level may play a role in the pathogenesis of ovulatory disfunction and insulin resistance in PCOS patients. Further studies are needed to understand the pathogenic and clinical significance of the IL-36 system in PCOS. (c) 2021 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.description.sponsorshipKarabuk University [17-KP-348]en_US
dc.description.sponsorshipThis work was supported by Karabuk University under Grant number 17-KP-348.en_US
dc.identifier.doi10.1016/j.tjog.2021.09.012
dc.identifier.endpage1022en_US
dc.identifier.issn1028-4559
dc.identifier.issue6en_US
dc.identifier.pmid34794731en_US
dc.identifier.scopus2-s2.0-85116535045en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1018en_US
dc.identifier.urihttps://doi.org/10.1016/j.tjog.2021.09.012
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5382
dc.identifier.volume60en_US
dc.identifier.wosWOS:000722376100010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Taiwanen_US
dc.relation.ispartofTaiwanese Journal of Obstetrics & Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPolycystic ovary syndromeen_US
dc.subjectObesityen_US
dc.subjectInterleukin-36en_US
dc.subjectAdiponectinen_US
dc.titleDecreased serum profile of the interleukin-36a in polycystic ovary syndromeen_US
dc.typeArticleen_US

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