Interactions between alcohol metabolism genes and religious involvement in association with maximum drinks and alcohol dependence symptoms

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dc.contributor.authorChartier, K.G.
dc.contributor.authorDick, D.M.
dc.contributor.authorAlmasy, L.
dc.contributor.authorChan, G.
dc.contributor.authorAliev, F.
dc.contributor.authorSchuckit, M.A.
dc.contributor.authorScott, D.M.
dc.date.accessioned2024-09-29T16:16:32Z
dc.date.available2024-09-29T16:16:32Z
dc.date.issued2016
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjective: Variations in the genes encoding alcohol dehydrogenase (ADH) enzymes are associated with both alcohol consumption and dependence in multiple populations. Additionally, some environmental factors have been recognized as modifiers of these relationships. This study examined the modifying effect of religious involvement on relationships between ADH gene variants and alcohol consumption-related phenotypes. Method: Subjects were African American, European American, and Hispanic American adults with lifetime exposure to alcohol (N = 7,716; 53% female) from the Collaborative Study on the Genetics of Alcoholism. Genetic markers included ADH1B-rs1229984, ADH1B-rs2066702, ADH1C-rs698, ADH4-rs1042364, and ADH4-rs1800759. Phenotypes were maximum drinks consumed in a 24-hour period and total number of alcohol dependence symptoms according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Religious involvement was defined by self-reported religious services attendance. Results: Both religious involvement and ADH1B-rs1229984 were negatively associated with the number of maximum drinks consumed and the number of lifetime alcohol dependence symptoms endorsed. The interactions of religious involvement with ADH1B-rs2066702, ADH1C-rs698, and ADH4-rs1042364 were significantly associated with maximum drinks and alcohol dependence symptoms. Risk variants had weaker associations with maximum drinks and alcohol dependence symptoms as a function of increasing religious involvement. Conclusions: This study provided initial evidence of a modifying effect for religious involvement on relationships between ADH variants and maximum drinks and alcohol dependence symptoms. © 2016, Alcohol Research Documentation Inc. All rights reserved.en_US
dc.description.sponsorshipInstitutes ofHealth; National Institute on AlcoholAbuse and Alcoholism, (K01AA021145, K02AA018755); National Institutes of Health, NIH, (HHSN268200782096C, U01HG004438); National Institute on Drug Abuse, NIDA; National Cancer Institute, NCI, (30 CA91842); National Center for Research Resources, NCRR, (UL1RR024992); Johns Hopkins University, JHU; Institute of Clinical and Translational Sciences, ICTS; Georgia Clinical and Translational Science Alliance, GaCTSA, (1RR024992)en_US
dc.identifier.doi10.15288/jsad.2016.77.393
dc.identifier.endpage404en_US
dc.identifier.issn1937-1888
dc.identifier.issue3en_US
dc.identifier.pmid27172571en_US
dc.identifier.scopus2-s2.0-84969134871en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage393en_US
dc.identifier.urihttps://doi.org/10.15288/jsad.2016.77.393
dc.identifier.urihttps://hdl.handle.net/20.500.14619/9159
dc.identifier.volume77en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAlcohol Research Documentation Inc.en_US
dc.relation.ispartofJournal of Studies on Alcohol and Drugsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdolescenten_US
dc.subjectAdulten_US
dc.subjectAfrican Americansen_US
dc.subjectAlcohol Dehydrogenaseen_US
dc.subjectAlcohol Drinkingen_US
dc.subjectAlcoholismen_US
dc.subjectEuropean Continental Ancestry Groupen_US
dc.subjectFemaleen_US
dc.subjectHispanic Americansen_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectPolymorphism, Single Nucleotideen_US
dc.subjectReligionen_US
dc.subjectalcohol dehydrogenaseen_US
dc.subjectadolescenten_US
dc.subjectadulten_US
dc.subjectAfrican Americanen_US
dc.subjectalcoholismen_US
dc.subjectCaucasianen_US
dc.subjectdrinking behavioren_US
dc.subjectfemaleen_US
dc.subjectgeneticsen_US
dc.subjectHispanicen_US
dc.subjecthumanen_US
dc.subjectmaleen_US
dc.subjectmiddle ageden_US
dc.subjectreligionen_US
dc.subjectsingle nucleotide polymorphismen_US
dc.titleInteractions between alcohol metabolism genes and religious involvement in association with maximum drinks and alcohol dependence symptomsen_US
dc.typeArticleen_US

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