The importance of plasma arginine level and its downstream metabolites in diagnosing prostate cancer

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dc.authoridBasar, Halil/0000-0003-1770-5165
dc.authoridSELVI, ISMAIL/0000-0003-3578-0732
dc.contributor.authorSelvi, Ismail
dc.contributor.authorBasar, Halil
dc.contributor.authorBaydilli, Numan
dc.contributor.authorMurat, Koza
dc.contributor.authorKaymaz, Ozlem
dc.date.accessioned2024-09-29T15:51:25Z
dc.date.available2024-09-29T15:51:25Z
dc.date.issued2019
dc.departmentKarabük Üniversitesien_US
dc.description.abstractPurpose There is still no certain threshold value of prostate-specific antigen (PSA) for prostate cancer diagnosis. We aimed to investigate the predictive value of arginine and its metabolites for diagnosing prostate cancer in patients with PSA 4-10 ng/ml and evaluate their usefulness as prognostic tumor markers. Methods Seventy-eight patients with a mean age of 64.505.49 years were included in our prospective observational study between November 2016 and March 2017. They were divided into two equal groups according to the pathologic results of prostate biopsy (benign vs. malignant). Plasma arginine and ornithine levels were analyzed before biopsy by liquid chromatography-tandem mass spectrometry. ELISA was used for analyzing urinary diacetylspermine. Results In PSA-adjusted analysis, the malignant group had lower plasma arginine levels (p=0.021) and arginine to ornithine ratio (AOR) (p=0.010), but higher plasma ornithine levels (p=0.012) and urinary diacetylspermine levels (p<0.001) as compared with the benign group. While arginine (r=-0.628, p<0.001) and AOR (r=-0.714, p<0.001) were negatively correlated with D'Amico clinical classification (p<0.001), ornithine (r=0.659, p<0.001) and diacetylspermine (r=0.710, p<0.001) were found to be positively correlated (p<0.001). In multivariate analysis, ornithine [OR 3.264, 95% CI (1.045-10.196), p=0.042] and diacetylspermine [OR 6.982, 95% CI (2.403-20.290), p<0.001] were found to be more significant in detection of prostate cancer. Conclusion Plasma arginine, ornithine, AOR and urinary diacetylspermine levels may be used as molecular markers to predict prostate biopsy outcomes in patients with PSA 4-10 ng/ml. But according to our results, the use of ornithine and diacethylspermine prior to biopsy seems to be the most cost-effective diagnostic strategy.en_US
dc.description.sponsorshipEducation and Planning Committee at Health Science University Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital [3]en_US
dc.description.sponsorshipThis work is financially supported by the Education and Planning Committee at Health Science University Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital through the scientific research fund with the decision of dated 20.10.2016 and numbered 3.en_US
dc.identifier.doi10.1007/s11255-019-02261-8
dc.identifier.endpage1983en_US
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue11en_US
dc.identifier.pmid31444697en_US
dc.identifier.startpage1975en_US
dc.identifier.urihttps://doi.org/10.1007/s11255-019-02261-8
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4067
dc.identifier.volume51en_US
dc.identifier.wosWOS:000501002800011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Urology and Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArginineen_US
dc.subjectDiacetylsperminen_US
dc.subjectOrnithineen_US
dc.subjectProstate biopsyen_US
dc.subjectProstate canceren_US
dc.subjectTumor markeren_US
dc.titleThe importance of plasma arginine level and its downstream metabolites in diagnosing prostate canceren_US
dc.typeArticleen_US

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