Protective effects of crocin on acrylamide-induced testis damage

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dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.authoridKayhan, Elif/0000-0002-0030-5862
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.contributor.authorGul, Mehmet
dc.contributor.authorKayhan Kustepe, Elif
dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorAltinoz, Eyup
dc.contributor.authorGozukara Bag, Harika Gozde
dc.contributor.authorGul, Semir
dc.contributor.authorGokturk, Nurcan
dc.date.accessioned2024-09-29T16:04:35Z
dc.date.available2024-09-29T16:04:35Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractExposure to acrylamide (Ac) through food is almost inevitable and this kind of toxicity may cause lifelong harm. In present study, we researched effects of Crocin (Cr) on testis histopathology in Ac-induced testis of rats. Adult male rats were grouped as: group 1, 1 ml saline only; group 2, 50 mg/kg Cr only; group 3, 25 mg/kg Ac only and group 4, 25 mg/kg Ac + 50 mg/kg Cr. All administrations were given as 1 ml/day by gavage for 21 days. It was found that Ac adversely influenced the levels of FSH, testosterone and LH in the blood serum; malondialdehyde (MDA), total antioxidant status (TOS), oxidative stress index (OSI)/ glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), total antioxidant status (TAS) oxidant/antioxidant parameters in testis tissue (p < .01) and the histopathological parameters like Johnson's score, seminiferous tubule diameter, seminiferous epithelial height and H-score for caspase-3 immunoreactivity. In contrary, Cr treatment resulted in increase in testosterone, follicle stimulating hormone (FSH), luteinizan hormone (LH) levels and SOD, CAT, GSH, TAS levels (p < .01) and improved all the histopathological changes. In conclusion, Cr has a promising protective potential against Ac-caused toxic damages in testicular tissue.en_US
dc.identifier.doi10.1111/and.14176
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue9en_US
dc.identifier.pmid34309867en_US
dc.identifier.scopus2-s2.0-85111699852en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/and.14176
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6213
dc.identifier.volume53en_US
dc.identifier.wosWOS:000678856400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectacrylamideen_US
dc.subjectcrocinen_US
dc.subjecthistopathologyen_US
dc.subjectoxidative stressen_US
dc.subjecttestisen_US
dc.titleProtective effects of crocin on acrylamide-induced testis damageen_US
dc.typeArticleen_US

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