Antioxidant and anti-inflammatory effect of olive leaf extract treatment in diabetic rat brain

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dc.contributor.authorBerköz, M.
dc.contributor.authorKahraman, T.
dc.contributor.authorShamsulddin, Z.N.
dc.contributor.authorKrosniak, M.
dc.date.accessioned2024-09-29T16:16:32Z
dc.date.available2024-09-29T16:16:32Z
dc.date.issued2023
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjectives: Olive (Olea europaea L.) plays a promising role in pharmaceutical, nutraceutical, and cosmetic production. On the other hand, olive leaf is widely used in folk medicine due to its antihyperglycemic activity. For this aim, possible effects of olive leaf extract (OLE) in the brain tissue of streptozotocin-induced diabetic rats were investigated. Methods: A total of 28 male rats were divided into four equal groups as control, diabetic (single dose of 45 mg/kg streptozotocin, i.p.), OLE (500 mg/kg/day), and diabetic + OLE groups. The study was terminated 21 days after the diabetes model was formed. At the end of the study, all the animals were sacrificed and blood and brain tissues were isolated. Relative brain weights, complete blood count, blood glycated hemoglobin, serum glucose, total protein, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, insulin, gonadal hormone levels, production and messenger ribonucleic acid (mRNA) levels of proinflammatory cytokines and mediators, total thiol, total oxidative stress, and total antioxidant status levels and fatty acid composition in brain tissue were measured in all study groups. Results: In diabetic rats, relative brain weight and serum insulin level decreased, glycated hemoglobin, oxidative stress, production and mRNA level of proinflammatory cytokines and mediators increased, hyperglycemia, hypercholesterolemia and hypertriglyceridemia, degraded fatty acid composition, anemia, leukopenia, and thrombocytopenia occurred. After OLE treatment, a remarkable improvement in most of these parameters, except gonadal hormones, has been observed in diabetic rats. Conclusions: This study suggests that olive leaf can be a precious neuroprotective agent in diabetes. © 2021 Walter de Gruyter GmbH, Berlin/Boston.en_US
dc.description.sponsorshipOffice of Scientific Research Projects of Van Yuzuncu Yil University, (TYL-2016-5106)en_US
dc.identifier.doi10.1515/jbcpp-2021-0054
dc.identifier.endpage196en_US
dc.identifier.issn0792-6855
dc.identifier.issue2en_US
dc.identifier.pmid34134180en_US
dc.identifier.scopus2-s2.0-85109032468en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage187en_US
dc.identifier.urihttps://doi.org/10.1515/jbcpp-2021-0054
dc.identifier.urihttps://hdl.handle.net/20.500.14619/9162
dc.identifier.volume34en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDe Gruyter Open Ltden_US
dc.relation.ispartofJournal of Basic and Clinical Physiology and Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectanti-inflammatoryen_US
dc.subjectantioxidanten_US
dc.subjectbrainen_US
dc.subjectdiabetesen_US
dc.subjectfatty acid compositionen_US
dc.subjectolive leaf extracten_US
dc.titleAntioxidant and anti-inflammatory effect of olive leaf extract treatment in diabetic rat brainen_US
dc.typeArticleen_US

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