The effects of pinealectomy and melatonin treatment in acrylamide-induced nephrotoxicity in rats: Antioxidant and anti-inflammatory mechanisms

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dc.authoridCetinavci, Dilan/0000-0002-4148-7711
dc.authoridDEMIR, MEHMET/0000-0001-6990-3337
dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.contributor.authorDemir, Mehmet
dc.contributor.authorAltinoz, Eyup
dc.contributor.authorCetinavci, Dilan
dc.contributor.authorElbe, Hulya
dc.contributor.authorBicer, Yasemin
dc.date.accessioned2024-09-29T16:00:32Z
dc.date.available2024-09-29T16:00:32Z
dc.date.issued2024
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjective: Acrylamide (AA) is toxic and forms in food that undergoes high-temperature processing. This study aimed to investigate the effects of AA-induced toxicity on renal tissue in pinealectomized rats and the possible protective effect of exogenous Melatonin (ML) administration. Materials and Methods: Sixty rats were randomized into 6 groups (n = 10): Sham, Sham+AA, Sham+AA+ML, PX, PX+AA, and PX+AA+ML. Sham and pinealectomized rats received AA (25 mg/kg/day orally) and ML (0.5 ml volume at 10 mg/kg/day, intraperitoneal) for 21 days. Results: The results showed that malondialdehyde (MDA), total oxidant status (TOS), oxidative stress index (OSI), tumor necrosis factor-alpha (TNF-alpha), and interleukin 113 (IL-113) levels of the kidney and urea and creatinine levels of serum in the PX (pinealectomy)+AA group were more increased than in the Sham+AA group. In addition, glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and total antioxidant status (TAS) levels decreased more in the PX+AA group than in the Sham+AA group. Also, we observed more histopathologic damage in the PX+AA group. On the other hand, up-regulation of kidney tissue antioxidants, down-regulation of tissue oxidants, and improvement in kidney function were achieved with ML treatment. Also, histopathological findings such as inflammatory cell infiltration, shrinkage of glomeruli, and dilatation of tubules caused by AA toxicity improved with ML treatment. Conclusion: ML supplementation exhibited adequate nephroprotective effects against the nephrotoxicity of AA on pinealectomized rat kidney tissue function by balancing the oxidant/antioxidant status and suppressing the release of proinflammatory cytokines.en_US
dc.identifier.doi10.1016/j.physbeh.2023.114450
dc.identifier.issn0031-9384
dc.identifier.issn1873-507X
dc.identifier.pmid38145817en_US
dc.identifier.scopus2-s2.0-85182159405en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.physbeh.2023.114450
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5209
dc.identifier.volume275en_US
dc.identifier.wosWOS:001147029100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofPhysiology & Behavioren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcrylamideen_US
dc.subjectPinealectomyen_US
dc.subjectMelatoninen_US
dc.subjectOxidative stressen_US
dc.subjectInflammationen_US
dc.titleThe effects of pinealectomy and melatonin treatment in acrylamide-induced nephrotoxicity in rats: Antioxidant and anti-inflammatory mechanismsen_US
dc.typeArticleen_US

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