Vestibular-evoked myogenic potentials, clinical evaluation, and imaging findings in multiple sclerosis

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dc.authoridBayir, Omer/0000-0001-9445-6129
dc.contributor.authorGuven, Hayat
dc.contributor.authorBayir, Omer
dc.contributor.authorAytac, Emrah
dc.contributor.authorOzdek, Ali
dc.contributor.authorComoglu, Selim Selcuk
dc.contributor.authorKorkmaz, Hakan
dc.date.accessioned2024-09-29T15:51:07Z
dc.date.available2024-09-29T15:51:07Z
dc.date.issued2014
dc.departmentKarabük Üniversitesien_US
dc.description.abstractVestibular-evoked myogenic potentials (VEMP), short-latency electromyographic responses elicited by acoustic stimuli, evaluate the function of vestibulocollic reflex and may give information about brainstem function. The aim of the present study is to evaluate the potential contribution of VEMP to the diagnosis of multiple sclerosis (MS). Fifty patients with MS and 30 healthy control subjects were included in this study. The frequency of VEMP p1-n1 and n2-p2 waves; mean p1, n1, n2, and p2 latency; and mean p1-n1 and n2-p2 amplitude were determined. The relation between clinical and imaging findings and VEMP parameters was evaluated. The p1-n1 and n2-p2 waves were more frequently absent in MS than in control subjects [p1-n1 wave absent: MS, 25 (25 %) ears; control, 6 (10 %) ears; P a parts per thousand currency sign 0.02] [n2-p2 wave absent: MS, 44 (44 %) ears; control, 7 (12 %) ears; P a parts per thousand currency sign 0.001]. The mean p1-n1 amplitude was lower in MS than in control subjects (MS, 19.1 +/- A 7.2 mu V; control, 23.3 +/- A 7.4 mu V; P a parts per thousand currency sign 0.002). A total of 24/50 (48 %) MS patients had VEMP abnormalities (absent responses and/or prolonged latencies). VEMP abnormalities were more frequent in patients with than without vestibular symptoms (P a parts per thousand currency sign 0.02) and with brainstem functional system score (FSS) a parts per thousand yen1 than FSS = 0 (P a parts per thousand currency sign 0.02). In patients with MS, absence of p1-n1 wave was more frequent in patients with than without vestibular symptoms [absence of p1-n1 wave: vestibular symptoms, 9 (45 %) ears; no vestibular symptoms, 16 (20 %) ears; P a parts per thousand currency sign 0.03] and patients with Expanded Disability Status Scale (EDSS) score a parts per thousand yen5.5 [absence of p1-n1 wave: EDSS a parts per thousand yen5.5, 7 (70 %) ears; EDSS < 5.5, 18 (20 %) ears; P a parts per thousand currency sign 0.001]. Abnormal VEMP may be noted in MS patients, especially those with vestibular symptoms and greater disability. The VEMP test may complement other studies for diagnosis and follow-up of patients with MS.en_US
dc.identifier.doi10.1007/s10072-013-1483-9
dc.identifier.endpage226en_US
dc.identifier.issn1590-1874
dc.identifier.issn1590-3478
dc.identifier.issue2en_US
dc.identifier.pmid23807120en_US
dc.identifier.scopus2-s2.0-84893830944en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage221en_US
dc.identifier.urihttps://doi.org/10.1007/s10072-013-1483-9
dc.identifier.urihttps://hdl.handle.net/20.500.14619/3905
dc.identifier.volume35en_US
dc.identifier.wosWOS:000330980100010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer-Verlag Italia Srlen_US
dc.relation.ispartofNeurological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMultiple sclerosisen_US
dc.subjectVestibular-evoked myogenic potentialsen_US
dc.subjectVestibulocollic reflexen_US
dc.subjectBrainstemen_US
dc.subjectDisabilityen_US
dc.titleVestibular-evoked myogenic potentials, clinical evaluation, and imaging findings in multiple sclerosisen_US
dc.typeArticleen_US

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