DNA binding studies of the 2,10,16,24-tetrakis (phenoxy-3-methoxybenzoic acid)phthalocyaninato) Co(II) and Cu(II) compounds

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dc.authoridBalli, Zekeriya/0000-0002-8311-5916
dc.authoridAGIRTAS, MEHMET SALIH/0000-0003-1296-2066
dc.contributor.authorBalli, Zekeriya
dc.contributor.authorArslantas, Ali
dc.contributor.authorSolgun, Derya Gungordu
dc.contributor.authorAgirtas, Mehmet Salih
dc.date.accessioned2024-09-29T15:54:53Z
dc.date.available2024-09-29T15:54:53Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractTetra phenoxy-3-methoxybenzoic acid substituted Co(II) and Cu(II) metal phthalocyanine compounds were reported for the first time. The structures of these compounds were elucidated by NMR, FT-IR, UV-vis spectroscopy, and elemental analysis. The UV/Vis, fluorescence spectra, viscosity and the thermal melting point techniques were implemented to analyze the DNA bonding activities of cobalt (II) and copper (II) complexes of phthalocyanine by calf thymus DNA. These techniques showed that the phthalocyanine complexes interacted with the DNA molecule through the intercalation mechanism. Additionally, among the methods above, the binding properties of DNA with the compounds 4 and 5 were studied by means of the agarose gel electrophoresis method. The complexes 4 and 5 bonded to the DNA molecule in the buffer system at a pH of 7.02. The findings of these methods proved that the Co(II) and Cu(II) complexes of phthalocyanine could be evaluated as potential cancer medicine for cancer treatment in the near future.en_US
dc.description.sponsorshipCommission of Scientific Research Projects of Karabuk University; Research Fund of Van Yuzuncu Yil University [FAP-2019-8345]en_US
dc.description.sponsorshipThis study was funded by the Commission of Scientific Research Projects of Karabuk University and the Research Fund of Van Yuzuncu Yil University (FAP-2019-8345).en_US
dc.identifier.doi10.1007/s42452-020-2640-4
dc.identifier.issn2523-3963
dc.identifier.issn2523-3971
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85100607298en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s42452-020-2640-4
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4325
dc.identifier.volume2en_US
dc.identifier.wosWOS:000532834300061en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Int Publ Agen_US
dc.relation.ispartofSn Applied Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAggregationen_US
dc.subjectSynthesisen_US
dc.subjectAbsorption spectroscopyen_US
dc.subjectDNA bindingen_US
dc.subjectGel electrophoresisen_US
dc.subjectPhthalocyanineen_US
dc.titleDNA binding studies of the 2,10,16,24-tetrakis (phenoxy-3-methoxybenzoic acid)phthalocyaninato) Co(II) and Cu(II) compoundsen_US
dc.typeArticleen_US

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