Prevention of toxic effects of orally administered tartrazine by crocin in Wistar rats

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dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.contributor.authorAltinoz, Eyup
dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorGul, Mehmet
dc.contributor.authorErdemli, Zeynep
dc.contributor.authorGul, Semir
dc.contributor.authorTurkoz, Yusuf
dc.date.accessioned2024-09-29T16:02:41Z
dc.date.available2024-09-29T16:02:41Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractTartrazine is used in the pharmaceutical, cosmetic, and food industries worldwide, despite its many toxic effects. The therapeutic effects of crocin (50mg/kg/day) against tartrazine-induced (500mg/kg/day) oxidative damage in ileum and colon tissues in rats have been investigated. Malondialdehyde and total oxidant status levels elevated by tartrazine within the ileum and colon tissues were reduced with crocin treatment, while tartrazine decreased antioxidative parameters (glutathione, total antioxidant status, superoxide dismutase, and catalase) were reverted. Tartrazine-induced histopathological changes of ileum and colon tissues were ameliorated following crocin treatment. In conclusion, Tartrazine consumption elicited tissue injury via lipid peroxidation, and crocin ameliorated oxidative injury by its antioxidant and free radical scavenger properties.en_US
dc.identifier.doi10.1080/02772248.2021.1942472
dc.identifier.endpage198en_US
dc.identifier.issn0277-2248
dc.identifier.issn1029-0486
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85108255490en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage184en_US
dc.identifier.urihttps://doi.org/10.1080/02772248.2021.1942472
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5649
dc.identifier.volume103en_US
dc.identifier.wosWOS:000685562600005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofToxicological and Environmental Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTartrazineen_US
dc.subjectcrocinen_US
dc.subjectoxidative stressen_US
dc.subjectmalondialdehydeen_US
dc.subjectileumen_US
dc.subjectcolonen_US
dc.titlePrevention of toxic effects of orally administered tartrazine by crocin in Wistar ratsen_US
dc.typeArticleen_US

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