Genetic Polymorphism on Chromosome 4q25 (rs17570669) May Predict Recurrence After Successful Electrical Cardioversion in Patients with Persistent Atrial Fibrillation

Basit Öğe Kaydı
dc.contributor.authorUlus, Taner
dc.contributor.authorAliyev, Ilkin
dc.contributor.authorArslan, Serap
dc.contributor.authorCilingir, Oguz
dc.contributor.authorColak, Ertugrul
dc.date.accessioned2024-09-29T16:09:51Z
dc.date.available2024-09-29T16:09:51Z
dc.date.issued2023
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjective: Direct current electrical cardioversion (DCCV) is an effective rhythm-control option for patients with atrial fibrillation (AF). Despite initial success, a high recurrence rate remains a significant challenge. There is limited data on the genetic predictors of AF recurrence following successful DCCV. In this study, we aimed to evaluate whether 11 single nucleotide polymorphisms (SNPs) previously associated with AF are also linked to recurrence after DCCV in the Turkish population. Methods: Seventy-five patients with persistent AF, who achieved stable sinus rhythm following DCCV, were included in the study. The patients were prospectively monitored for the onset of AF recurrence. Clinical characteristics and SNPs were analyzed and compared between patients who experienced recurrence and those who did not. Results: The average age of the patients was 61.9 +/- 11.5, and 33 (44%) were female. Over an average follow-up period of 17.0 (11.0-25.0) months, AF recurrence was observed in 38 patients (50.7%). A SNP in the PITX2 gene (rs17570669) (OR: 9.00, 95% Confidence Interval (CI): 1.28-63.02) and another in the ZFHX3 gene (rs2106261) (OR: 8.96, 95% CI: 1.03-77.66) were notably associated with AF recurrence in the additive model (P = 0.027 and 0.047, respectively). Multivariate Cox regression analysis revealed that the rs17570669 SNP was the sole independent predictor of AF recurrence (Hazard Ratio (HR): 3.59, 95% CI: 1.05-12.21, P = 0.040). Conclusion: The SNP in the paired-like homeodomain 2 (PITX2) gene (rs17570669) emerges as an independent predictor for AF recurrence after successful electrical cardioversion.en_US
dc.identifier.doi10.5543/tkda.2023.37679
dc.identifier.endpage556en_US
dc.identifier.issn1016-5169
dc.identifier.issn1308-4488
dc.identifier.issue8en_US
dc.identifier.pmid38164777en_US
dc.identifier.scopus2-s2.0-85181415498en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage550en_US
dc.identifier.trdizinid1253845en_US
dc.identifier.urihttps://doi.org/10.5543/tkda.2023.37679
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1253845
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7816
dc.identifier.volume51en_US
dc.identifier.wosWOS:001125254700011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofTurk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAtrial fibrillationen_US
dc.subjectelectrical cardioversionen_US
dc.subjectsingle nucleotide polymorphismen_US
dc.titleGenetic Polymorphism on Chromosome 4q25 (rs17570669) May Predict Recurrence After Successful Electrical Cardioversion in Patients with Persistent Atrial Fibrillationen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu