Positive effect of curcumin on experimental peridontitis via suppression of IL-1-beta and IL-6 expression level

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dc.authoridHakki, Sema/0000-0001-8665-6235
dc.authoridBozkurt, Serife Buket/0000-0002-8641-2844
dc.contributor.authorAy, Zuhal Yetkin
dc.contributor.authorBakir, Burcu
dc.contributor.authorBozkurt, Serife Buket
dc.contributor.authorKayis, Seyit Ali
dc.contributor.authorHakki, Sema Sezgin
dc.date.accessioned2024-09-29T16:01:00Z
dc.date.available2024-09-29T16:01:00Z
dc.date.issued2022
dc.departmentKarabük Üniversitesien_US
dc.description.abstractThis study examined the effect of curcumin on T-helper (Th17) and T-regulatory (Treg) cells regarding the mRNA of cytokines/mediators in the gingiva. Thirty-five male albino Wistar rats were divided into four groups: Group 1: periodontitis (n = 9): Group 2: periodontitis with curcumin treatment (n = 8): Group 3: periodontally healthy with curcumin treatment (n = 10); and Group 4: periodontally healthy (n = 8). Curcumin was administered via oral gavage (30 mg/kg/day) for a total of 15 days. The gingival tissues were investigated regarding mRNA expressions of Th17/Treg cytokines with qRT-PCR. The distributional properties of the data were evaluated using the Anderson-Darling normality test. Kruskal-Wallis and Mann-Whitney U tests were employed for multiple group comparisons. Partial least squares regression discriminant analysis (PLS-DA) was used to evaluate the degree of contribution of each mRNA to the separation of treatment groups. When the periodontitis groups were compared, curcumin treatment resulted in lower IL-1 beta (Group 2 median: 0.002, Group 1 median: 0.12) and IL-6 (Group 2 median: 0.031, Group 1 median: 0.078) and higher IL-17 (Group 2 median: 1.07, Group 1 median: 0.583) relative mRNA expression in Group 2 than in Group 1 (p < 0.001). Group 3 also had higher IL-10 relative expression (median: 0.067) than Groups 1 and 4 (median: 0.028, 0.007, respectively. p < 0.001). These results indicate that curcumin might be a promising agent for the prevention and/or treatment of periodontal diseases due to its decreasing effect on IL-1 beta and IL-6 mRNA expression.en_US
dc.description.sponsorshipTUBITAK [114S908]; Coordination Unit of Scientific Investigations, Suleyman Demirel University, Isparta, Turkey [3849-D1-14]en_US
dc.description.sponsorshipThe presented part of the study (gingival mRNA expressions of mediators related to Treg and Th17 cells) was supported by TUBITAK (#114S908). The previously published and currently cited part of the study (experimental periodontitis, the histological and biochemical results cited in the discussion section) was supported by the Coordination Unit of Scientific Investigations, Suleyman Demirel University, Isparta, Turkey (project number: 3849-D1-14).en_US
dc.identifier.doi10.1024/0300-9831/a000672
dc.identifier.endpage239en_US
dc.identifier.issn0300-9831
dc.identifier.issn1664-2821
dc.identifier.issue3-4en_US
dc.identifier.pmid32718217en_US
dc.identifier.scopus2-s2.0-85089174114en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage231en_US
dc.identifier.urihttps://doi.org/10.1024/0300-9831/a000672
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5485
dc.identifier.volume92en_US
dc.identifier.wosWOS:000827944100009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherImr Pressen_US
dc.relation.ispartofInternational Journal For Vitamin and Nutrition Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcurcuminen_US
dc.subjectTh17en_US
dc.subjectTregen_US
dc.subjectIL-17en_US
dc.subjectIL-23en_US
dc.subjectexperimental periodontitisen_US
dc.titlePositive effect of curcumin on experimental peridontitis via suppression of IL-1-beta and IL-6 expression levelen_US
dc.typeArticleen_US

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