Effect of chemotherapy exposure prior to pregnancy on fetal brain tissue and the potential protective role of quercetin

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dc.authoridkocahan, sayad/0000-0002-3161-1280
dc.contributor.authorDogan, Z.
dc.contributor.authorKocahan, S.
dc.contributor.authorErdemli, E.
dc.contributor.authorKose, E.
dc.contributor.authorYilmaz, I.
dc.contributor.authorEkincioglu, Z.
dc.contributor.authorEkinci, N.
dc.date.accessioned2024-09-29T15:51:13Z
dc.date.available2024-09-29T15:51:13Z
dc.date.issued2015
dc.departmentKarabük Üniversitesien_US
dc.description.abstractCyclophosphamide (CYC) and doxorubicin (DOX) are among the most effective and widely used anticancer chemotherapeutic drugs. Potential chemopreventive and chemotherapeutic functions have recently been attributed to flavonoids. We hypothesized that Quercetin (QR) would protect against the toxic effects of chemotherapeutic agents applied prior to pregnancy. Rats were treated with the chemotherapeutic drugs CYC (27 mg/kg) and DOX (1.8 mg/kg) applied in a single intraperitoneal dose once every 3 weeks for 10 weeks. QR was administered at a dose of 10 mg/kg/day by oral gavage. 48 h following the experimental chemotherapy exposure, female rats were transferred to cages containing male rat for mating. Fetal brain tissues were removed from fetuses extracted by cesarean section on the 20th day of gestation for evaluation of antioxidant parameters. A significant increase in superoxide dismutase and malondialdehyde activity was observed in CYC and DOX treatment groups relative to the control group (p < 0.05). Similarly, carnitine acylcarnitine translocase and Glutathione activity was significantly reduced in the CYC and DOX groups relative to the control group (p < 0.05). Our results indicate that the use of chemotherapeutic drugs before pregnancy can result in oxidative damage to fetal brain tissue. Therefore, women who have been exposed to chemotherapy and may become pregnant should be treated with antioxidant compounds such as QR to reduce the risk of damage to fetal brain tissues.en_US
dc.description.sponsorshipInonu University [INU-BAP 2010/58]en_US
dc.description.sponsorshipThis research was supported by Inonu University Research Fund (INU-BAP 2010/58).en_US
dc.identifier.doi10.1007/s10616-014-9742-z
dc.identifier.endpage1038en_US
dc.identifier.issn0920-9069
dc.identifier.issn1573-0778
dc.identifier.issue6en_US
dc.identifier.pmid25260542en_US
dc.identifier.scopus2-s2.0-84946474935en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1031en_US
dc.identifier.urihttps://doi.org/10.1007/s10616-014-9742-z
dc.identifier.urihttps://hdl.handle.net/20.500.14619/3937
dc.identifier.volume67en_US
dc.identifier.wosWOS:000364225200013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofCytotechnologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChemotherapyen_US
dc.subjectCyclophosphamideen_US
dc.subjectDoxorubicinen_US
dc.subjectFetal developmenten_US
dc.subjectQuercetinen_US
dc.titleEffect of chemotherapy exposure prior to pregnancy on fetal brain tissue and the potential protective role of quercetinen_US
dc.typeArticleen_US

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