The protective and therapeutic effects of linalool against doxorubicin-induced cardiotoxicity in Wistar albino rats

Basit Öğe Kaydı
dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.authoridONER, ZULAL/0000-0003-0459-1015
dc.contributor.authorOner, Z.
dc.contributor.authorAltinoz, E.
dc.contributor.authorElbe, H.
dc.contributor.authorEkinci, N.
dc.date.accessioned2024-09-29T16:05:02Z
dc.date.available2024-09-29T16:05:02Z
dc.date.issued2019
dc.departmentKarabük Üniversitesien_US
dc.description.abstractThe aim of the present study was to determine the protective and therapeutic effects of linalool (LIN) against doxorubicin (DOX)-induced cardiotoxicity in rats histologically and biochemically. In experiments, 64 male Wistar albino rats were randomly divided into eight groups (n = 8). These groups were control (C) (0.9% saline solution), DOX (20 mg/kg DOX), LIN50 (50 mg/kg LIN), LIN100 (100 mg/kg LIN), DOX + LIN50 (20 mg/kg DOX and 50 mg/kg LIN), DOX + LIN100 (20 mg/kg DOX and 100 mg/kg LIN), LIN50 + DOX (50 mg/kg LIN and 20 mg/kg DOX), and LIN100 + DOX (100 mg/kg LIN and 20 mg/kg DOX). It was determined that necrosis and extensive inflammatory cell infiltration were observed in the DOX group. It was determined that histopathological changes significantly decreased in groups treated with LIN after DOX administration. While the caspase-3 immunostaining was highly evident in DOX group apoptotic cells (p < 0.001, for all), the intensity of caspase-3 immunostaining in the treatment groups decreased (p < 0.05). While DOX administration resulted in a significant increase in malondialdehyde (MDA) levels and plasma Creatine kinase (CK) and lactate dehydrogenase (LDH) levels in cardiac tissue when compared to the C groups, it was observed that DOX + LIN administration led to a significant decrease in MDA, plasma CK and LDH levels and a significant increase in glutathione (GSH), superoxide dismutase, and catalase enzyme levels. Finally, it was concluded that DOX led to heavy cardiotoxicity and DOX + LIN administration could remove cardiomyopathy symptoms.en_US
dc.description.sponsorshipTUBITAK 1002 Fast Support Program [216S330]en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was sponsored by TUBITAK 1002 (project no. 216S330) Fast Support Program.en_US
dc.identifier.doi10.1177/0960327119842634
dc.identifier.endpage813en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue7en_US
dc.identifier.pmid30977406en_US
dc.identifier.scopus2-s2.0-85064530483en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage803en_US
dc.identifier.urihttps://doi.org/10.1177/0960327119842634
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6477
dc.identifier.volume38en_US
dc.identifier.wosWOS:000473503800006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDoxorubicinen_US
dc.subjectlinaloolen_US
dc.subjectcardiotoxicityen_US
dc.subjectMDAen_US
dc.subjectcaspase-3en_US
dc.subjectoxidative stressen_US
dc.titleThe protective and therapeutic effects of linalool against doxorubicin-induced cardiotoxicity in Wistar albino ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu