Predicting Alcohol Dependence Symptoms by Young Adulthood: A Co-Twin Comparisons Study

Basit Öğe Kaydı
dc.authoridKsinan, Albert/0000-0003-3900-5098
dc.authoridKaprio, Jaakko/0000-0002-3716-2455
dc.authoridVuoksimaa, Eero/0000-0002-6534-3667
dc.contributor.authorStephenson, Mallory
dc.contributor.authorBarr, Peter
dc.contributor.authorAliev, Fazil
dc.contributor.authorKsinan, Albert
dc.contributor.authorLatvala, Antti
dc.contributor.authorVuoksimaa, Eero
dc.contributor.authorViken, Richard
dc.date.accessioned2024-09-29T16:00:58Z
dc.date.available2024-09-29T16:00:58Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractCo-twin comparisons address familial confounding by controlling for genetic and environmental influences that twin siblings share. We applied the co-twin comparison design to investigate associations of adolescent factors with alcohol dependence (AD) symptoms. Participants were 1286 individuals (581 complete twin pairs; 42% monozygotic; and 54% female) from the FinnTwin12 study. Predictors included adolescent academic achievement, substance use, externalizing problems, internalizing problems, executive functioning, peer environment, physical health, relationship with parents, alcohol expectancies, life events, and pubertal development. The outcome was lifetime AD clinical criterion count, as measured in young adulthood. We examined associations of each adolescent domain with AD symptoms in individual-level and co-twin comparison analyses. In individual-level analyses, adolescents with higher levels of substance use, teacher-reported externalizing problems at age 12, externalizing problems at age 14, self- and co-twin-reported internalizing problems, peer deviance, and perceived difficulty of life events reported more symptoms of AD in young adulthood (ps < .044). Conversely, individuals with higher academic achievement, social adjustment, self-rated health, and parent-child relationship quality met fewer AD clinical criteria (ps < .024). Associations between adolescent substance use, teacher-reported externalizing problems, co-twin-reported internalizing problems, peer deviance, self-rated health, and AD symptoms were of a similar magnitude in co-twin comparisons. We replicated many well-known adolescent correlates of later alcohol problems, including academic achievement, substance use, externalizing and internalizing problems, self-rated health, and features of the peer environment and parent-child relationship. Furthermore, we demonstrate the utility of co-twin comparisons for understanding pathways to AD. Effect sizes corresponding to the associations between adolescent substance use, teacher-reported externalizing problems, co-twin-reported internalizing problems, peer deviance, and self-rated health were not significantly attenuated (p value threshold = .05) after controlling for genetic and environmental influences that twin siblings share, highlighting these factors as candidates for further research.en_US
dc.description.sponsorshipNational Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health [R01AA012502, R01AA015416, K02AA018755, K01AA024152]; Academy of Finland [265240, 308248, 312073, 308698, 314196, 100499, 205585, 118555, 141054, 263278, 264146]en_US
dc.description.sponsorshipThis work was supported by the National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health under award numbers R01AA012502, R01AA015416, K02AA018755, and K01AA024152; and the Academy of Finland (grants 100499, 205585, 118555, 141054, 265240, 263278, and 264146). JK and AL have been supported by the Academy of Finland (grants 265240, 263278, 308248, and 312073 to JK; grants 308698 and 314196 to AL). The content is solely the responsibility of the authors and does not necessarily represent the official views of the funders.en_US
dc.identifier.doi10.1017/thg.2021.36
dc.identifier.endpage216en_US
dc.identifier.issn1832-4274
dc.identifier.issn1839-2628
dc.identifier.issue4en_US
dc.identifier.pmid34526173en_US
dc.identifier.scopus2-s2.0-85115156507en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage204en_US
dc.identifier.urihttps://doi.org/10.1017/thg.2021.36
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5464
dc.identifier.volume24en_US
dc.identifier.wosWOS:000721262500005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofTwin Research and Human Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdolescenceen_US
dc.subjectalcoholen_US
dc.subjectco-twin comparisonsen_US
dc.subjectlongitudinalen_US
dc.subjectyoung adultsen_US
dc.titlePredicting Alcohol Dependence Symptoms by Young Adulthood: A Co-Twin Comparisons Studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu