Structural and biological assessment of boron doped bioactive glass nanoparticles for dental tissue applications

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dc.authoridAlshemary, Ammar Z/0000-0001-5367-1869
dc.authoridTezcaner, Aysen/0000-0003-4292-5856
dc.authoridEvis, Zafer/0000-0002-7518-8162
dc.contributor.authorRad, Rezai Moonesi
dc.contributor.authorAlshemary, Ammar Z.
dc.contributor.authorEvis, Zafer
dc.contributor.authorKeskin, Dilek
dc.contributor.authorAltunbas, Korhan
dc.contributor.authorTezcaner, Aysen
dc.date.accessioned2024-09-29T15:55:06Z
dc.date.available2024-09-29T15:55:06Z
dc.date.issued2018
dc.departmentKarabük Üniversitesien_US
dc.description.abstractIn this article, bioactive glass nanoparticles (BG-NPs) doped with boron were synthesized and characterized to evaluate their effects on human dental pulp stem cells (hDPSCs). All synthesized BGs were nano-sized and amorphous in nature. They showed the expected characteristic functional groups and composition close to the designed ones by microstructural characterizations. Porositimetry analysis revealed that increase of boron in the BG composition caused a decrease in the specific surface area, average pore diameter and total pore volume of NPs. hDPSCs were isolated from third molar teeth of patients and were shown to have the characteristics of mesenchymal stem cells. Dose dependent cytotoxicity study of boron doped BG-NPs suggested that 6.25 mg/ml was the optimum concentration for cells. ALP activity tests and intracellular calcium measurements revealed enhanced early stage odontogenic differentiation of hDPSCs treated with 6.25 mg/ml of different BG groups. Immunocytochemical staining showed positive effect of boron doped BG-NPs on DSPP, osteopontin and collagen I markers expression of hDPSCs. Our results indicated that boron doped BG-NPs hold potential as biomaterial in regenerative dentistry.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [114R042]en_US
dc.description.sponsorshipWe would like to thank The Scientific and Technological Research Council of Turkey for the financial support through the project 114R042.en_US
dc.identifier.doi10.1016/j.ceramint.2018.02.230
dc.identifier.endpage9864en_US
dc.identifier.issn0272-8842
dc.identifier.issn1873-3956
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-85042932904en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage9854en_US
dc.identifier.urihttps://doi.org/10.1016/j.ceramint.2018.02.230
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4463
dc.identifier.volume44en_US
dc.identifier.wosWOS:000430522200143en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofCeramics Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDental tissue engineeringen_US
dc.subjectNano bioactive glassen_US
dc.subjectBoronen_US
dc.subjectDental pulp stem cellsen_US
dc.subjectRegenerative dentistryen_US
dc.titleStructural and biological assessment of boron doped bioactive glass nanoparticles for dental tissue applicationsen_US
dc.typeArticleen_US

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