Comparison of Intravenous Lipid Emulsion, Bicarbonate, and Glucagon Treatments in a Rabbit Model of Clomipramine Toxicity

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dc.authoridUNLU, ALI/0000-0002-9991-3939
dc.authoridKara, Hasan/0000-0002-3839-7651
dc.authoridAK, AHMET/0000-0002-9617-8772
dc.authoridBayir, Aysegul/0000-0002-5680-031X
dc.contributor.authorKara, Hasan
dc.contributor.authorBayir, Aysegul
dc.contributor.authorAk, Ahmet
dc.contributor.authorUnlu, Ali
dc.contributor.authorKayis, Seyit Ali
dc.date.accessioned2024-09-29T16:06:44Z
dc.date.available2024-09-29T16:06:44Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground: This experimental study aimed to evaluate intravenous lipid emulsion, sodium bicarbonate, and glucagon as treatment options for the cardiotoxicity associated with clomipramine, a tricyclic antidepressant, and the antidotal effects of these drugs. Methods: In this experimental study, female and male New Zealand rabbits were divided into a sham group, a sodium bicarbonate treatment group, an intravenous lipid emulsion treatment group, and a glucagon treatment group. After the administration of a single dose of oral clomipramine (70 mg/kg), through an orogastric tube, vital parameters such as mean arterial pressure and oxygen saturation were measured, using a bedside monitor. Intoxication was established after the mean arterial pressure decreased to 40%-45%, within approximately 30-45 minutes. Treatments were administered after intoxication was established. Results: Although the mean arterial pressure values significantly changed over time in the sham and glucagon treatment groups, no significant changes were observed in the intravenous lipid emulsion and sodium bicarbonate treatment groups. Significant differences were observed among the values at 0 min compared with 30, 60, and 120 min in both the sham and the glucagon treatment groups. The clomipramine level changed significantly in all groups. Conclusion: Tricyclic antidepressant poisoning remains a difficult therapeutic challenge. Glucagon, a lipophilic drug, appears to be a promising candidate for the treatment of clomipramine-induced cardiotoxicity and should be considered early for the treatment of severe tricyclic antidepressant overdose.en_US
dc.description.sponsorshipSelcuk Universitesi Bilimsel Arastirma Projeleri Koordinatorluguen_US
dc.description.sponsorshipSelcuk Universitesi Bilimsel Arastirma Projeleri Koordinatorluguen_US
dc.identifier.doi10.22514/sv.2020.16.0033
dc.identifier.endpage43en_US
dc.identifier.issn1334-5605
dc.identifier.issn1845-206X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85094571103en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage37en_US
dc.identifier.urihttps://doi.org/10.22514/sv.2020.16.0033
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7013
dc.identifier.volume16en_US
dc.identifier.wosWOS:000583292400032en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMre Pressen_US
dc.relation.ispartofSigna Vitaeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTCA intoxicationen_US
dc.subjectGlucagonen_US
dc.subjectSodium bicarbonateen_US
dc.subjectIntravenous lipid emulsionen_US
dc.subjectAntidotesen_US
dc.titleComparison of Intravenous Lipid Emulsion, Bicarbonate, and Glucagon Treatments in a Rabbit Model of Clomipramine Toxicityen_US
dc.typeArticleen_US

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