Microstructural, Biomechanical, and In Vitro Studies of Ti-Nb-Zr Alloys Fabricated by Powder Metallurgy

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dc.authoridKaya, Mehmet/0000-0001-9710-2254
dc.authoridCETIN, YUKSEL/0000-0001-5101-3870
dc.authoridHuang, Yan/0000-0002-6315-5224
dc.authoridIncesu, Alper/0000-0003-4404-4331
dc.contributor.authorKarakurt, Eyyup Murat
dc.contributor.authorCetin, Yuksel
dc.contributor.authorIncesu, Alper
dc.contributor.authorDemirtas, Huseyin
dc.contributor.authorKaya, Mehmet
dc.contributor.authorYildizhan, Yasemin
dc.contributor.authorTosun, Merve
dc.date.accessioned2024-09-29T16:08:08Z
dc.date.available2024-09-29T16:08:08Z
dc.date.issued2023
dc.departmentKarabük Üniversitesien_US
dc.description.abstractThis study investigated the microstructures, mechanical performances, corrosion resistances, and in vitro studies of porous Ti-xNb-10Zr (x: 10 and 20; at. %) alloys. The alloys were fabricated by powder metallurgy with two categories of porosities, i.e., 21-25% and 50-56%, respectively. The space holder technique was employed to generate the high porosities. Microstructural analysis was performed by using various methods including scanning electron microscopy, energy dispersive spectroscopy, electron backscatter diffraction, and x-ray diffraction. Corrosion resistance was assessed via electrochemical polarisation tests, while mechanical behavior was determined by uniaxial compressive tests. In vitro studies, such as cell viability and proliferation, adhesion potential, and genotoxicity, were examined by performing an MTT assay, fibronectin adsorption, and plasmid-DNA interaction assay. Experimental results showed that the alloys had a dual-phase microstructure composed of finely dispersed acicular hcp & alpha;-Ti needles in the bcc & beta;-Ti matrix. The ultimate compressive strength ranged from 1019 MPa to 767 MPa for alloys with 21-25% porosities and from 173 MPa to 78 MPa for alloys with 50-56% porosities. Noted that adding a space holder agent played a more critical role in the mechanical behaviors of the alloys compared to adding niobium. The pores were largely open and exhibited irregular shapes, with uniform size distribution, allowing for cell ingrowth. Histological analysis showed that the alloys studied met the biocompatibility criteria required for orthopaedic biomaterial use.en_US
dc.description.sponsorshipEPSRC Future LiME Hub [EP/N007638/1]; Republic of Turkey Ministry of National Educationen_US
dc.description.sponsorshipThe EPSRC Future LiME Hub (EP/N007638/1); PhD studentship, the Republic of Turkey Ministry of National Education.en_US
dc.identifier.doi10.3390/ma16124240
dc.identifier.issn1996-1944
dc.identifier.issue12en_US
dc.identifier.pmid37374426en_US
dc.identifier.scopus2-s2.0-85163837944en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/ma16124240
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7383
dc.identifier.volume16en_US
dc.identifier.wosWOS:001017428300001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofMaterialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectpowder metallurgyen_US
dc.subjectporosityen_US
dc.subjectspace holder techniqueen_US
dc.subjectcorrosion resistanceen_US
dc.subjectbiocompabilityen_US
dc.titleMicrostructural, Biomechanical, and In Vitro Studies of Ti-Nb-Zr Alloys Fabricated by Powder Metallurgyen_US
dc.typeArticleen_US

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