Could aortic arch calcification help in detection of hypertensive retinopathy?

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dc.authoridCakan, Fahri/0000-0002-5427-3480
dc.contributor.authorAdar, Adem
dc.contributor.authorOnalan, Orhan
dc.contributor.authorSevik, Ozge
dc.contributor.authorTurgut, Yeliz
dc.contributor.authorCakan, Fahri
dc.date.accessioned2024-09-29T16:03:11Z
dc.date.available2024-09-29T16:03:11Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjective Hypertension-induced end-organ damage is one of the important determinants of morbidity and mortality in patients with hypertension. All types of hypertension-induced end-organ damages start with vascular damage. Vascular calcification is a marker of vascular damage and aortic arch calcification (AAC) is one of the easily identifiable types of vascular calcification. We hypothesized that AAC predicts retinopathy in hypertensive patients. Methods Consecutive hypertensive patients without diabetes mellitus were included. Chest radiography in the posterior-anterior was used to assess the presence of AAC. All patients underwent ophthalmologic examination for retinopathy. Results We included 495 hypertensive patients in this study. Of these, 306 (62%) had hypertensive retinopathy. Patients with hypertensive retinopathy had significantly higher prevalence of AAC as compared to the patients without hypertensive retinopathy (88% vs. 22%, P < 0.001). We found a strong and positive correlation between hypertensive retinopathy and AAC grades (r = 639, P < 0.001). Receiver operator characteristics curve analysis yielded a strong predictive ability of AAC for the presence of hypertensive retinopathy [area under curve = 0.814, 95% confidence interval (CI): 0.775-0.853, P < 0.0001]. In multivariate logistic regression analysis, presence of AAC [odds ratio (OR) 13.128; CI: 7.894-21.832] and serum glucose levels (OR 1.020; CI: 1.003-1.037) were strongly and independently associated with hypertensive retinopathy. Conclusion Presence of AAC on chest radiograph is strongly and independently associated with retinopathy in nondiabetic hypertensive patients. This simple, inexpensive and widely available tool may help in early detection of retinopathy in patients with hypertension.en_US
dc.identifier.doi10.1097/MBP.0000000000000498
dc.identifier.endpage123en_US
dc.identifier.issn1359-5237
dc.identifier.issn1473-5725
dc.identifier.issue2en_US
dc.identifier.pmid33234808en_US
dc.identifier.scopus2-s2.0-85102602264en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage118en_US
dc.identifier.urihttps://doi.org/10.1097/MBP.0000000000000498
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5935
dc.identifier.volume26en_US
dc.identifier.wosWOS:000639295000006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofBlood Pressure Monitoringen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectaortic arch calcificationen_US
dc.subjecthypertensionen_US
dc.subjectretinopathyen_US
dc.titleCould aortic arch calcification help in detection of hypertensive retinopathy?en_US
dc.typeArticleen_US

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