Investigation of pre-operative demographic, biochemical, sonographic and cytopathological findings in low-risk thyroid neoplasms

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dc.authoridNasiroglu Imga, Narin/0000-0001-8013-230X
dc.authoridaksoy altinboga, aysegul/0000-0003-1484-7619
dc.contributor.authorDeniz, Muzaffer Serdar
dc.contributor.authorOzdemir, Didem
dc.contributor.authorImga, Narin Nasiroglu
dc.contributor.authorBaser, Huesniye
dc.contributor.authorSeyrek, Fatma Neslihan Cuhaci
dc.contributor.authorAltinboga, Ayseguel Aksoy
dc.contributor.authorTopaloglu, Oya
dc.date.accessioned2024-09-29T16:04:39Z
dc.date.available2024-09-29T16:04:39Z
dc.date.issued2023
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjectiveThe present article analyses pre-operative demographic, biochemical, sonographic and histopathological characteristics of low-risk thyroid neoplasms (LRTNs), with a focus on four subgroups, well-differentiated carcinoma-not otherwise specified (WDC-NOS), non-invasive follicular thyroid neoplasm with papillary like nuclear features (NIFTP), well-differentiated tumours of uncertain malignant potential (WDT-UMP) and follicular tumour of uncertain malignant potential (FT-UMP).MethodsThe study retrospectively analyzed the histopathology of 2453 malignant thyroids and the final analyses included 99 cases diagnosed with LRTNs. The demographic and clinical features, pre-operative thyroid function, ultrasonography results, cytopathology results, histopathology results and prognostic classifications were assessed.ResultsThe groups were similar demographic characteristics and the majority of clinical data, including comorbidities, thyroid function tests, thyroid cancer/neck radiotherapy history. NIFTPs represented 69.7% of all LRTNs. All (100%) WDT-UMPs had solitary nodules. Index nodule volume differed among the groups (p = .036), it was the lowest in WDC-NOS [0.68 (0.63-0.72 cc)] and highest in FT-UMP [12.6 (0.5-64 cc)]. Echogenicity findings were similar. Index nodule TIRADS demonstrated a significant difference (p = .021) but index nodule halo sign and BETHESDA scores were similar in all groups. The diameter, localisation and multicentric structure of LRTNs were again similar for all groups. Finally, prognostic scores suggested similar outcomes in all groups.ConclusionThe majority of LRTNs were NIFTPs in our population and all WDT-UMPs were solitary lesions. Index nodule volume was the most essential discriminating sonographic finding but further research must be performed before discriminatory potential can be described.en_US
dc.identifier.doi10.1111/cen.14965
dc.identifier.endpage510en_US
dc.identifier.issn0300-0664
dc.identifier.issn1365-2265
dc.identifier.issue5en_US
dc.identifier.pmid37708141en_US
dc.identifier.scopus2-s2.0-85170855590en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage502en_US
dc.identifier.urihttps://doi.org/10.1111/cen.14965
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6223
dc.identifier.volume99en_US
dc.identifier.wosWOS:001065684200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectfollicular tumour of uncertain malignant potentialen_US
dc.subjectlow-risk thyroid neoplasmsen_US
dc.subjectnon-invasive follicular thyroid neoplasm with papillary-like nuclear featuresen_US
dc.subjectwell-differentiated carcinoma-not otherwise specifieden_US
dc.subjectwell-differentiated tumours of uncertain malignant potentialen_US
dc.titleInvestigation of pre-operative demographic, biochemical, sonographic and cytopathological findings in low-risk thyroid neoplasmsen_US
dc.typeArticleen_US

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