The protective role of N-acetylcysteine against acrylamide-induced genotoxicity and oxidative stress in rats

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dc.contributor.authorAltinoz, E.
dc.contributor.authorTurkoz, Y.
dc.date.accessioned2024-09-29T16:22:05Z
dc.date.available2024-09-29T16:22:05Z
dc.date.issued2014
dc.departmentKarabük Üniversitesien_US
dc.description.abstractAcrylamide is neurotoxic, genotoxic and highly carcinogenic in humans and animals. The aim of this study was to research the protective role of N-acetylcysteine against acrylamide-induced genotoxicity and oxidative stress in rats. In the present study, male wistar albino rats were divided into four groups, each containing 10 as follows: Control (C) group, Acrylamide (AA) group, N-acetylcysteine (NAC) group, Acrylamide + N-acetylcysteine (AA+NAC) group. At the end of 21 days, Malondialdehyde (MDA) and Glutathione (GSH) levels were measured in plasma and DNA damage was observed in lymphocytes. Plasma GSH level decreased significantly in AA group compared to C group (P < 0.05). However, GSH level increased significantly in AA+NAC group compared to AA group (p< 0.05). MDA levels increased significantly in AA group compared to C group (p< 0.05). But AA+NAC administration decreased MDA levels as compared to AA group (p< 0.05). Comet analysis results showed that lymphocyte DNAs were normal appearance in C and NAC groups. DNA damage was observed at a highest level in AA group. Furthermore some lymphocytes exhibited apoptotic appearance. However this damage was prevented by NAC administration on lymphocyte DNAs significantly. Our results demonstrated that high level of AA caused oxidative stress and DNA damage, but NAC could have a protective role on acrylamide-induced toxicity.en_US
dc.identifier.endpage43en_US
dc.identifier.issn1529-9120
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84902179105en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage35en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14619/9805
dc.identifier.volume16en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGene Therapy and Molecular Biologyen_US
dc.relation.ispartofGene Therapy and Molecular Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcrylamideen_US
dc.subjectGenotoxicityen_US
dc.subjectLymphocyteen_US
dc.subjectN-acetylcysteineen_US
dc.subjectOxidative stressen_US
dc.titleThe protective role of N-acetylcysteine against acrylamide-induced genotoxicity and oxidative stress in ratsen_US
dc.typeArticleen_US

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