An unusual case of asymptomatic diffuse alveolar hemorrhage related to amiodarone induced INR elevation
Küçük Resim Yok
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Ondokuz Mayis Universitesi
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Pulmonary adverse effects of amiodarone are among the important causesof morbidity. Such effects may rarely manifest as diffuse alveolar hemorrhage. Another important amiodarone-induced adverse effect is hepatotoxicity. Hepatotoxicity mostly presents as asymptomatic elevation of the liver enzymes. To the best of our knowledge, in amiodarone-induced hepatotoxicity, AST and ALT elevations are well known; however, there are no clear data regarding the high International Normalized Ratio (INR) levels in such a condition. In the present report, we describe the case of a patient under management with chronic low-dose amiodarone, who was admitted to the emergency department for lingual hematoma. During the assessment for bleeding diathesis, the INR was found to be 8.59. After excluding all other possible causes for the high INR level, amiodarone was suggested to be the cause. Since there were diffuse infiltrations on chest x-ray, the patient underwent thorax tomography. Asymptomatic diffuse alveolar hemorrhage secondary to INR elevation was considered. This patient is the first case who had amiodarone-induced INR elevation, and as a consequence, developed asymptomatic diffuse alveolar hemorrhage. © 2019 OMU
Açıklama
Anahtar Kelimeler
Amiodarone toxicity Diffuse alveolar hemorrhage Elevated international normalized ratio
Kaynak
Journal of Experimental and Clinical Medicine (Turkey)
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
36
Sayı
2
