An unusual case of asymptomatic diffuse alveolar hemorrhage related to amiodarone induced INR elevation

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dc.contributor.authorAdar, A.
dc.contributor.authorOnalan, O.
dc.contributor.authorCakan, F.
dc.date.accessioned2024-09-29T16:16:01Z
dc.date.available2024-09-29T16:16:01Z
dc.date.issued2019
dc.departmentKarabük Üniversitesien_US
dc.description.abstractPulmonary adverse effects of amiodarone are among the important causesof morbidity. Such effects may rarely manifest as diffuse alveolar hemorrhage. Another important amiodarone-induced adverse effect is hepatotoxicity. Hepatotoxicity mostly presents as asymptomatic elevation of the liver enzymes. To the best of our knowledge, in amiodarone-induced hepatotoxicity, AST and ALT elevations are well known; however, there are no clear data regarding the high International Normalized Ratio (INR) levels in such a condition. In the present report, we describe the case of a patient under management with chronic low-dose amiodarone, who was admitted to the emergency department for lingual hematoma. During the assessment for bleeding diathesis, the INR was found to be 8.59. After excluding all other possible causes for the high INR level, amiodarone was suggested to be the cause. Since there were diffuse infiltrations on chest x-ray, the patient underwent thorax tomography. Asymptomatic diffuse alveolar hemorrhage secondary to INR elevation was considered. This patient is the first case who had amiodarone-induced INR elevation, and as a consequence, developed asymptomatic diffuse alveolar hemorrhage. © 2019 OMUen_US
dc.identifier.doi10.5835/jecm.omu.36.02.005
dc.identifier.endpage61en_US
dc.identifier.issn1309-4483
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85105339736en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage59en_US
dc.identifier.urihttps://doi.org/10.5835/jecm.omu.36.02.005
dc.identifier.urihttps://hdl.handle.net/20.500.14619/8786
dc.identifier.volume36en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherOndokuz Mayis Universitesien_US
dc.relation.ispartofJournal of Experimental and Clinical Medicine (Turkey)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmiodarone toxicity Diffuse alveolar hemorrhage Elevated international normalized ratioen_US
dc.titleAn unusual case of asymptomatic diffuse alveolar hemorrhage related to amiodarone induced INR elevationen_US
dc.typeArticleen_US

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