Experimental study of in-vitro bioanalysis and in-vivo living tissue biocompatibility of Mg-Zn alloys

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dc.authoridCicek, Dr. Bunyamin/0000-0002-6603-7178
dc.contributor.authorComba, Bahat
dc.contributor.authorCicek, Bunyamin
dc.contributor.authorComba, Arzu
dc.contributor.authorSancak, Tunahan
dc.contributor.authorAkveran, Gonul Arslan
dc.contributor.authorKoc, Erkan
dc.contributor.authorSun, Yavuz
dc.date.accessioned2024-09-29T16:06:20Z
dc.date.available2024-09-29T16:06:20Z
dc.date.issued2023
dc.departmentKarabük Üniversitesien_US
dc.description.abstractIn this study in-vitro bioanalysis and in-vivo living tissue biocompatibility were evaluated. Pure Mg and Mg + x Zn (x = 1 and 3 wt%) alloys have been used in the study. In vitro immersion and potentiodynamic corrosion were applied to these alloys in Hank's and artificial seawater solution. The materials were kept in living tissue (gluteus-superficial) for 7 weeks in-vivo (albino-rat). After 4 and 7 week, the control and experimental groups' urine parameters, blood mineral substance levels, and radiographic image controls were evaluated. It was observed that the bio-dissolution level decreased as the Zn-ratio increased. As a result, successful results were obtained in the biocompatible and biodegradable material class of Zn-doped Mg alloys used in the study. The dissolution amount of 1.03 mm/y (for Mg + 3Zn alloy) in Hank's solution was calculated. The % vitality was determined at the level of 117%.en_US
dc.description.sponsorshipScientific Research Projects Department of Hitit University [ALACA19001.19.001]en_US
dc.description.sponsorshipWe would like to thank the Scientific Research Projects Department of Hitit University for this project (Project no: ALACA19001.19.001). For the animal experiments carried out in this project, Van Yuzuncu Yil University (Tuerkiye) Ethics Committee approved approval numbered 2019/09 was obtained. A patent application has been filed on Determination of a biomaterial, which includes all the experimental steps used in this study.en_US
dc.identifier.doi10.1557/s43578-023-00950-w
dc.identifier.endpage2212en_US
dc.identifier.issn0884-2914
dc.identifier.issn2044-5326
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-85148650851en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2203en_US
dc.identifier.urihttps://doi.org/10.1557/s43578-023-00950-w
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6779
dc.identifier.volume38en_US
dc.identifier.wosWOS:000939926200003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofJournal of Materials Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlbino raten_US
dc.subjectBiocorrosionen_US
dc.subjectBiomaterialen_US
dc.subjectMg alloysen_US
dc.subjectTissue implanten_US
dc.titleExperimental study of in-vitro bioanalysis and in-vivo living tissue biocompatibility of Mg-Zn alloysen_US
dc.typeArticleen_US

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