Intergenerational Continuity in Parents' and Adolescents' Externalizing Problems: The Role of Life Events and Their Interaction With GABRA2

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dc.authoridYan, Jia/0000-0003-0506-5957
dc.authoridSalvatore, Jessica/0000-0001-5504-5087
dc.authoridKaprio, Jaakko/0000-0002-3716-2455
dc.authoridLansford, Jennifer/0000-0003-1956-4917
dc.contributor.authorSalvatore, Jessica E.
dc.contributor.authorMeyers, Jacquelyn L.
dc.contributor.authorYan, Jia
dc.contributor.authorAliev, Fazil
dc.contributor.authorLansford, Jennifer E.
dc.contributor.authorPettit, Gregory S.
dc.contributor.authorBates, John E.
dc.date.accessioned2024-09-29T16:01:01Z
dc.date.available2024-09-29T16:01:01Z
dc.date.issued2015
dc.departmentKarabük Üniversitesien_US
dc.description.abstractWe examine whether parental externalizing behavior has an indirect effect on adolescent externalizing behavior via elevations in life events, and whether this indirect effect is further qualified by an interaction between life events and adolescents' GABRA2 genotype (rs279871). We use data from 2 samples: the Child Development Project (CDP; n = 324) and FinnTwin12 (n = 802). In CDP, repeated measures of life events, mother-reported adolescent externalizing, and teacher-reported adolescent externalizing were used. In FinnTwin12, life events and externalizing were assessed at age 14. Parental externalizing was indexed by measures of antisocial behavior and alcohol problems or alcohol dependence symptoms in both samples. In CDP, parental externalizing was associated with more life events, and the association between life events and subsequent adolescent externalizing varied as a function of GABRA2 genotype (p <= .05). The association between life events and subsequent adolescent externalizing was stronger for adolescents with 0 copies of the G minor allele compared to those with 1 or 2 copies of the minor allele. Parallel moderation trends were observed in FinnTwin12 (p <= .11). The discussion focuses on how the strength of intergenerational pathways for externalizing psychopathology may differ as a function of adolescent-level individual differences.en_US
dc.description.sponsorshipNational Institute of Mental Health [MH42498, MH56961, MH57024, MH057024-07S1, MH57095]; Eunice Kennedy Shriver National Institute of Child Health and Human Development [HD30572]; National Institute on Drug Abuse [DA016903]; National Institute of Alcohol Abuse and Alcoholism [AA12502, AA00145, AA-09203, AA15416, K02AA018755]; Academy of Finland [100499, 205585, 141054, 118555, 265240, 263278, 264146]; Academy of Finland Centre of Excellence Programme [213506, 129680]; TUBI-TAK [114C117]; [T32MH20030-14]; [F32AA022269]en_US
dc.description.sponsorshipThe Child Development Project has been funded by Grants MH42498, MH56961, MH57024, MH057024-07S1 (supplemental funds to collect DNA), and MH57095 from the National Institute of Mental Health; HD30572 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development; and DA016903 from the National Institute on Drug Abuse. The Finnish Twin studies have been supported by the National Institute of Alcohol Abuse and Alcoholism (Grants AA12502, AA00145, and AA-09203 to Richard J. Rose and AA15416 and K02AA018755 to Danielle M. Dick), the Academy of Finland (Grants 100499, 205585, 141054, 118555, 265240, 263278, and 264146 to Jaakko Kaprio), and the Academy of Finland Centre of Excellence Programme (Lea Pulkkinen and Grants 213506 and 129680 to Jaakko Kaprio). Jessica E. Salvatore was supported by T32MH20030-14 and F32AA022269. Fazil Aliev was supported by TUBI-TAK Grant #114C117. The contents of the article are solely the responsibility of the authors and do not necessarily represent the official views of the funders.en_US
dc.identifier.doi10.1037/abn0000066
dc.identifier.endpage728en_US
dc.identifier.issn0021-843X
dc.identifier.issn1939-1846
dc.identifier.issue3en_US
dc.identifier.pmid26075969en_US
dc.identifier.scopus2-s2.0-84938971775en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage709en_US
dc.identifier.urihttps://doi.org/10.1037/abn0000066
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5488
dc.identifier.volume124en_US
dc.identifier.wosWOS:000359379000021en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Psychological Assocen_US
dc.relation.ispartofJournal of Abnormal Psychologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectexternalizingen_US
dc.subjectGABRA2en_US
dc.subjectgene-environment interactionen_US
dc.subjectlife eventsen_US
dc.subjectintergenerational continuityen_US
dc.titleIntergenerational Continuity in Parents' and Adolescents' Externalizing Problems: The Role of Life Events and Their Interaction With GABRA2en_US
dc.typeArticleen_US

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