Adenovirus-36 infection and obesity: A case control study of Turkish women with polycystic ovary syndrome
Küçük Resim Yok
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Sci Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background and aims: Adenovirus-36 (Ad-36) seropositivity has been shown to be involved in the aetiology of obesity. The aim of this study was to examine Ad-36 positivity in obese and normal-weight patients with polycystic ovary syndrome (PCOS). Methods: There were two groups including 92 and 110 subjects. This study was a prospective casecontrol study. The enzyme-immunoassay method was used to quantitatively determine antibodies (Abs) specific to human Ad-36 in the serum samples. Age, body mass index (BMI), fasting glucose levels and insulin levels of the participants were recorded. The PCOS and control group patients were divided into two groups: the overweight group with BMI >= 25 kg/m(2) and non-obese group with BMI <25 kg/m(2). Results: Ad-36 Ab positivity in the PCOS group was found to be significantly higher than that in the control group (p < 0.001). Ad-36 Ab positivity was significantly higher in the PCOS obese group than in the control obese group (p < 0.001). Ad-36 Ab positivity and BMI >= 25 kg/m(2) were identified as independent predictors of PCOS in logistic regression analysis. Conclusion: Ad-36 Ab positivity was significantly higher in the obese/overweight PCOS patients. Obesity can be prevented in patients with PCOS by treating Ad-36. (C) 2021 Diabetes India. Published by Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Polycystic ovary syndrome, Obesity, Adenovirus-36, Homeostasis model assessment of insulin resistance
Kaynak
Diabetes & Metabolic Syndrome-Clinical Research & Reviews
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
15
Sayı
1
