Dynamic thiol/disulphide homeostasis in patients with Uterine Myoma

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dc.authoridneselioglu, salim/0000-0002-0974-5717
dc.contributor.authorEroglu, Semra
dc.contributor.authorHaskul, Ismail
dc.contributor.authorAziz, Vusale
dc.contributor.authorYurtcu, Engin
dc.contributor.authorKaratas, Fatih
dc.contributor.authorNeselioglu, Salim
dc.contributor.authorErel, Ozcan
dc.date.accessioned2024-09-29T15:55:17Z
dc.date.available2024-09-29T15:55:17Z
dc.date.issued2017
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground: The aim of this study is to measure and compare the dynamic thiol and disulphide homeostasis between patients with Uterine Myoma (UM) and healthy subjects. Material and method: A total of 54 patients with UM who were diagnosed by transvaginal ultrasonography and 37 age-and body mass index-matched healthy individuals were included in this study. Thiol/disulphide homeostasis was measured by a novel automatic spectrophotometric method. Results: The mean serum native thiol, disulphide, and thiol levels were statistically lower in UM group than those in the control group [(284.66 +/- 59.41 mu mol/L vs. 320.98 +/- 56.17 mu mol/L, P < 0.0001), (17.27 +/- 5.59 mu mol/L vs. 22.38 +/- 6.93 mu mol/L P < 0.0001) and (319.21 +/- 61.69 vs. 365.76 +/- 61.46 mu mol/L, P < 0.0001), respectively]. There were no statistically significant differences in ratios of the disulphide/native thiol: native thiol/total thiol, and disulphide/total thiol among patients with UM versus healthy control group (P = 0.096, 0.092, 0.092, respectively). Conclusion: It was found that the native thiol, total thiol, and disulphide levels in patients with UM decreased while the ratio of native thiol/disulphide remained unchanged. It is necessary to investigate whether these findings have a role in the etiology and clinical course of the UM. (C) 2017 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejogrb.2017.06.045
dc.identifier.endpage26en_US
dc.identifier.issn0301-2115
dc.identifier.issn1872-7654
dc.identifier.pmid28697394en_US
dc.identifier.scopus2-s2.0-85021929304en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage24en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejogrb.2017.06.045
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4574
dc.identifier.volume216en_US
dc.identifier.wosWOS:000411771700004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofEuropean Journal of Obstetrics & Gynecology and Reproductive Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSerumen_US
dc.subjectThiolen_US
dc.subjectDisulphideen_US
dc.subjectRatioen_US
dc.subjectUterine myomaen_US
dc.titleDynamic thiol/disulphide homeostasis in patients with Uterine Myomaen_US
dc.typeArticleen_US

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