Investigation of DNA-Binding Activities of Zinc(II) and Cobalt(II) Phthalocyanine Compounds with 3,4,5-Trimethoxybenzyloxy Substituents

Küçük Resim Yok

Tarih

2017

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Wiley-V C H Verlag Gmbh

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

In this study, DNA-binding activities of previously synthesized tetrakis(3,4,5-trimethoxybenzyloxy)-substituted Zn(II) and Co(II) phthalocyanines (Pc4 and Pc5) have been chosen for the study. The interaction of synthesized tetrakis(3,4,5-trimethoxybenzyloxy)-substituted Zn(II) and Co(II) phthalocyanine compounds with CT-DNA was investigated by using UV/Vis titrimetric method, fluorescence spectroscopy, cyclic voltammetry, thermal denaturation profile, gel electrophoresis and viscosty measurement in a Tris-HCI buffer at pH 7.0. The results indicated that tetrakis(3,4,5-trimethoxybenzyloxy)-substituted Zn(II) and Co(II) phthalocyanines (Pc4 and Pc5) can interact with CT-DNA via intercalation binding mode.

Açıklama

Anahtar Kelimeler

Calf Thymus-DANN, DNA binding, Phthalocyanine compounds, UV-Vis spectroscopy

Kaynak

Chemistryselect

WoS Q Değeri

Q3

Scopus Q Değeri

Q2

Cilt

2

Sayı

35

Künye