Investigation of DNA-Binding Activities of Zinc(II) and Cobalt(II) Phthalocyanine Compounds with 3,4,5-Trimethoxybenzyloxy Substituents

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dc.contributor.authorArslantas, Ali
dc.contributor.authorAgirtas, Mehmet Salih
dc.date.accessioned2024-09-29T15:50:50Z
dc.date.available2024-09-29T15:50:50Z
dc.date.issued2017
dc.departmentKarabük Üniversitesien_US
dc.description.abstractIn this study, DNA-binding activities of previously synthesized tetrakis(3,4,5-trimethoxybenzyloxy)-substituted Zn(II) and Co(II) phthalocyanines (Pc4 and Pc5) have been chosen for the study. The interaction of synthesized tetrakis(3,4,5-trimethoxybenzyloxy)-substituted Zn(II) and Co(II) phthalocyanine compounds with CT-DNA was investigated by using UV/Vis titrimetric method, fluorescence spectroscopy, cyclic voltammetry, thermal denaturation profile, gel electrophoresis and viscosty measurement in a Tris-HCI buffer at pH 7.0. The results indicated that tetrakis(3,4,5-trimethoxybenzyloxy)-substituted Zn(II) and Co(II) phthalocyanines (Pc4 and Pc5) can interact with CT-DNA via intercalation binding mode.en_US
dc.description.sponsorshipCommittee for Scientific Research Projects at Karabuk Universityen_US
dc.description.sponsorshipThis study was supported by the Committee for Scientific Research Projects at Karabuk University.en_US
dc.identifier.doi10.1002/slct.201702362
dc.identifier.endpage11665en_US
dc.identifier.issn2365-6549
dc.identifier.issue35en_US
dc.identifier.scopus2-s2.0-85041840052en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage11659en_US
dc.identifier.urihttps://doi.org/10.1002/slct.201702362
dc.identifier.urihttps://hdl.handle.net/20.500.14619/3744
dc.identifier.volume2en_US
dc.identifier.wosWOS:000418400400044en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistryselecten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCalf Thymus-DANNen_US
dc.subjectDNA bindingen_US
dc.subjectPhthalocyanine compoundsen_US
dc.subjectUV-Vis spectroscopyen_US
dc.titleInvestigation of DNA-Binding Activities of Zinc(II) and Cobalt(II) Phthalocyanine Compounds with 3,4,5-Trimethoxybenzyloxy Substituentsen_US
dc.typeArticleen_US

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