Strontium doped injectable bone cement for potential drug delivery applications
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Bv
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Microwave assisted wet precipitation method was used to synthesize calcium deficient strontium doped beta-tricalcium phosphate (Sr-beta TCP) with a chemical formula of Ca2.96-xSrx(PO4)(2). beta-FICP was reacted with monocalcium phosphate monohydrate [Ca(H2PO4)(2)center dot H2O, MCPM] in presence of water to furnish corresponding Sr containing brushite cement (Sr-Brc). The samples were characterized by using X-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FTIR) and field emission scanning electron microscopy (FESEM). Strontium content in the prepared samples was determined by using inductively coupled plasma optical emission spectrometry (ICP-OES). The effect of Sr2+ ions on the structural, mechanical, setting properties and drug release of the cement is reported. Incorporation of Sr2+ ions improved the injectability, setting time and mechanical properties of the Brc The release profiles of antibiotics incorporated in Brc and Sr-Brc confirmed that the Sr incorporation into the Brc results in the efficient release of the antibiotics from the cement. (C) 2017 Elsevier B.V. All rights reserved.
Açıklama
Anahtar Kelimeler
Brushite, Dicalcium phosphate, Antibiotics, Strontium, Drug delivery
Kaynak
Materials Science & Engineering C-Materials For Biological Applications
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
80
