Strontium doped injectable bone cement for potential drug delivery applications

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dc.authoridAlshemary, Ammar Z/0000-0001-5367-1869
dc.authoridJawad, Zaidoon/0000-0002-8863-4977
dc.contributor.authorTaha, Ali
dc.contributor.authorAkram, Muhammad
dc.contributor.authorJawad, Zaidoon
dc.contributor.authorAlshemary, Ammar Z.
dc.contributor.authorHussain, Rafaqat
dc.date.accessioned2024-09-29T16:00:27Z
dc.date.available2024-09-29T16:00:27Z
dc.date.issued2017
dc.departmentKarabük Üniversitesien_US
dc.description.abstractMicrowave assisted wet precipitation method was used to synthesize calcium deficient strontium doped beta-tricalcium phosphate (Sr-beta TCP) with a chemical formula of Ca2.96-xSrx(PO4)(2). beta-FICP was reacted with monocalcium phosphate monohydrate [Ca(H2PO4)(2)center dot H2O, MCPM] in presence of water to furnish corresponding Sr containing brushite cement (Sr-Brc). The samples were characterized by using X-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FTIR) and field emission scanning electron microscopy (FESEM). Strontium content in the prepared samples was determined by using inductively coupled plasma optical emission spectrometry (ICP-OES). The effect of Sr2+ ions on the structural, mechanical, setting properties and drug release of the cement is reported. Incorporation of Sr2+ ions improved the injectability, setting time and mechanical properties of the Brc The release profiles of antibiotics incorporated in Brc and Sr-Brc confirmed that the Sr incorporation into the Brc results in the efficient release of the antibiotics from the cement. (C) 2017 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.msec.2017.05.117
dc.identifier.endpage101en_US
dc.identifier.issn0928-4931
dc.identifier.issn1873-0191
dc.identifier.pmid28866230en_US
dc.identifier.scopus2-s2.0-85019904356en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage93en_US
dc.identifier.urihttps://doi.org/10.1016/j.msec.2017.05.117
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5157
dc.identifier.volume80en_US
dc.identifier.wosWOS:000410254400012en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofMaterials Science & Engineering C-Materials For Biological Applicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrushiteen_US
dc.subjectDicalcium phosphateen_US
dc.subjectAntibioticsen_US
dc.subjectStrontiumen_US
dc.subjectDrug deliveryen_US
dc.titleStrontium doped injectable bone cement for potential drug delivery applicationsen_US
dc.typeArticleen_US

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