Genes associated with alcohol outcomes show enrichment of effects with broad externalizing and impulsivity phenotypes in an independent sample
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Alcohol Research Documentation Inc.
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: The purpose of this study was to evaluate evidence for association with a panel of genes previously associated with alcohol-related traits in a new sample of adolescent and young adult individuals (N = 2,128; 51% female) collected as part of the Collaborative Study on the Genetics of Alcoholism (COGA). We tested for association with phenotypes related to externalizing behavior, including diagnostic symptom counts for disorders on the externalizing spectrum (alcohol dependence, conduct disorder, adult antisocial personality disorder, and illicit drug dependence), and related behavioral/personality traits (Achenbach Externalizing, NEO Extraversion, NEO Conscientiousness, Zuckerman’s Sensation Seeking, and the Barratt Impulsivity Scale) based on the substantial literature suggesting that these behaviors may be alternate manifestations of a shared genetic liability.; Method: We tested for overall enrichment of the set of 215 genotyped single-nucleotide polymorphisms (SNPs) for each of the phenotypes. We conducted secondary analyses comparing results for sensation seeking with results for the other phenotypes.; Results: For all phenotypes, there was signifi- cant enrichment of association results (p <.05) compared with chance expectations. The greatest number of significant results was observed with the phenotype Sensation Seeking. Secondary analyses indicated that the number of SNPs yielding p <.05 with Sensation Seeking was significantly greater than that observed for each of the other phenotypes.; Conclusions: We find evidence for enrichment of association results across a spectrum of externalizing phenotypes with a panel of candidate genes/SNPs selected based on previous suggestion of association with alcohol-related outcomes. In particular, we find significant enrichment of effects with sensation seeking, suggesting that this may be a particularly salient behavior associated with risk for alcohol-related problems. © 2015, Alcohol Research Documentation Inc.. All rights reserved.
Açıklama
Anahtar Kelimeler
Adolescent, Adult, Alcoholism, Antisocial Personality Disorder, Child, Conduct Disorder, Female, Genotype, Humans, Impulsive Behavior, Male, Phenotype, Polymorphism, Single Nucleotide, Prospective Studies, Substance-Related Disorders, Young Adult, adolescent, adult, alcoholism, antisocial personality disorder, child, clinical trial, conduct disorder, female, genetics, genotype, human, impulsiveness, male, phase 4 clinical trial, phenotype, prospective study, single nucleotide polymorphism, Substance-Related Disorders, young adult
Kaynak
Journal of Studies on Alcohol and Drugs
WoS Q Değeri
Scopus Q Değeri
Q1
Cilt
76
Sayı
1
