Genes associated with alcohol outcomes show enrichment of effects with broad externalizing and impulsivity phenotypes in an independent sample

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dc.contributor.authorAliev, F.
dc.contributor.authorWetherill, L.
dc.contributor.authorBierut, L.
dc.contributor.authorBucholz, K.K.
dc.contributor.authorEdenberg, H.
dc.contributor.authorForoud, T.
dc.contributor.authorDick, D.M.
dc.date.accessioned2024-09-29T16:16:32Z
dc.date.available2024-09-29T16:16:32Z
dc.date.issued2015
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjective: The purpose of this study was to evaluate evidence for association with a panel of genes previously associated with alcohol-related traits in a new sample of adolescent and young adult individuals (N = 2,128; 51% female) collected as part of the Collaborative Study on the Genetics of Alcoholism (COGA). We tested for association with phenotypes related to externalizing behavior, including diagnostic symptom counts for disorders on the externalizing spectrum (alcohol dependence, conduct disorder, adult antisocial personality disorder, and illicit drug dependence), and related behavioral/personality traits (Achenbach Externalizing, NEO Extraversion, NEO Conscientiousness, Zuckerman’s Sensation Seeking, and the Barratt Impulsivity Scale) based on the substantial literature suggesting that these behaviors may be alternate manifestations of a shared genetic liability.; Method: We tested for overall enrichment of the set of 215 genotyped single-nucleotide polymorphisms (SNPs) for each of the phenotypes. We conducted secondary analyses comparing results for sensation seeking with results for the other phenotypes.; Results: For all phenotypes, there was signifi- cant enrichment of association results (p <.05) compared with chance expectations. The greatest number of significant results was observed with the phenotype Sensation Seeking. Secondary analyses indicated that the number of SNPs yielding p <.05 with Sensation Seeking was significantly greater than that observed for each of the other phenotypes.; Conclusions: We find evidence for enrichment of association results across a spectrum of externalizing phenotypes with a panel of candidate genes/SNPs selected based on previous suggestion of association with alcohol-related outcomes. In particular, we find significant enrichment of effects with sensation seeking, suggesting that this may be a particularly salient behavior associated with risk for alcohol-related problems. © 2015, Alcohol Research Documentation Inc.. All rights reserved.en_US
dc.description.sponsorshipNational Institute on Alcohol Abuse and Alcoholism, NIAAA, (K02AA018755); National Institute on Alcohol Abuse and Alcoholism, NIAAAen_US
dc.identifier.doi10.15288/jsad.2015.76.38
dc.identifier.endpage46en_US
dc.identifier.issn1937-1888
dc.identifier.issue1en_US
dc.identifier.pmid25486392en_US
dc.identifier.scopus2-s2.0-84916608733en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage38en_US
dc.identifier.urihttps://doi.org/10.15288/jsad.2015.76.38
dc.identifier.urihttps://hdl.handle.net/20.500.14619/9160
dc.identifier.volume76en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAlcohol Research Documentation Inc.en_US
dc.relation.ispartofJournal of Studies on Alcohol and Drugsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdolescenten_US
dc.subjectAdulten_US
dc.subjectAlcoholismen_US
dc.subjectAntisocial Personality Disorderen_US
dc.subjectChilden_US
dc.subjectConduct Disorderen_US
dc.subjectFemaleen_US
dc.subjectGenotypeen_US
dc.subjectHumansen_US
dc.subjectImpulsive Behavioren_US
dc.subjectMaleen_US
dc.subjectPhenotypeen_US
dc.subjectPolymorphism, Single Nucleotideen_US
dc.subjectProspective Studiesen_US
dc.subjectSubstance-Related Disordersen_US
dc.subjectYoung Adulten_US
dc.subjectadolescenten_US
dc.subjectadulten_US
dc.subjectalcoholismen_US
dc.subjectantisocial personality disorderen_US
dc.subjectchilden_US
dc.subjectclinical trialen_US
dc.subjectconduct disorderen_US
dc.subjectfemaleen_US
dc.subjectgeneticsen_US
dc.subjectgenotypeen_US
dc.subjecthumanen_US
dc.subjectimpulsivenessen_US
dc.subjectmaleen_US
dc.subjectphase 4 clinical trialen_US
dc.subjectphenotypeen_US
dc.subjectprospective studyen_US
dc.subjectsingle nucleotide polymorphismen_US
dc.subjectSubstance-Related Disordersen_US
dc.subjectyoung adulten_US
dc.titleGenes associated with alcohol outcomes show enrichment of effects with broad externalizing and impulsivity phenotypes in an independent sampleen_US
dc.typeArticleen_US

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