Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elife Sciences Publications Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,390 complete twin pairs born 18861994. Although genetic variance showed a generally increasing trend across the birth-year cohorts, heritability estimates (0.69-0.84 in men and 0.53-0.78 in women) did not present any clear pattern of secular changes. Comparing geographic-cultural regions (Europe, North America and Australia, and East Asia), total height variance was greatest in North America and Australia and lowest in East Asia, but no clear pattern in the heritability estimates across the birth-year cohorts emerged. Our findings do not support the hypothesis that heritability of height is lower in populations with low living standards than in affluent populations, nor that heritability of height will increase within a population as living standards improve.
Açıklama
Anahtar Kelimeler
Body-Mass Index, Genome-Wide Association, Twin, Infancy, Loci, Age
Kaynak
Elife
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
5
