Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

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dc.authoridPahlen, Shandell/0000-0003-0753-4155
dc.authoridHotopf, Matthew/0000-0002-3980-4466
dc.authoridInui, Fujio/0000-0002-7164-2081
dc.authoridHuibregtse, Brooke/0000-0003-0977-7249
dc.authoridHjelmborg, Jacob/0000-0001-9630-9149
dc.authoridRasmussen, Finn/0000-0001-7915-7809
dc.authoridvan Beijsterveldt, Toos/0000-0002-6617-4201
dc.contributor.authorJelenkovic, Aline
dc.contributor.authorHur, Yoon-Mi
dc.contributor.authorSund, Reijo
dc.contributor.authorYokoyama, Yoshie
dc.contributor.authorSiribaddana, Sisira H.
dc.contributor.authorHotopf, Matthew
dc.contributor.authorSumathipala, Athula
dc.date.accessioned2024-09-29T16:10:02Z
dc.date.available2024-09-29T16:10:02Z
dc.date.issued2016
dc.departmentKarabük Üniversitesien_US
dc.description.abstractHuman height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,390 complete twin pairs born 18861994. Although genetic variance showed a generally increasing trend across the birth-year cohorts, heritability estimates (0.69-0.84 in men and 0.53-0.78 in women) did not present any clear pattern of secular changes. Comparing geographic-cultural regions (Europe, North America and Australia, and East Asia), total height variance was greatest in North America and Australia and lowest in East Asia, but no clear pattern in the heritability estimates across the birth-year cohorts emerged. Our findings do not support the hypothesis that heritability of height is lower in populations with low living standards than in affluent populations, nor that heritability of height will increase within a population as living standards improve.en_US
dc.description.sponsorshipSuomen Akatemia [266592]; MRC [G120/635] Funding Source: UKRI; Grants-in-Aid for Scientific Research [16H03261, 26671010, 15H05105] Funding Source: KAKENen_US
dc.description.sponsorshipSuomen Akatemia 266592 Karri Silventoinenr The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.en_US
dc.identifier.doi10.7554/eLife.20320
dc.identifier.issn2050-084X
dc.identifier.pmid27964777en_US
dc.identifier.scopus2-s2.0-85006379669en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.7554/eLife.20320
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7917
dc.identifier.volume5en_US
dc.identifier.wosWOS:000391277600001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElife Sciences Publications Ltden_US
dc.relation.ispartofElifeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBody-Mass Indexen_US
dc.subjectGenome-Wide Associationen_US
dc.subjectTwinen_US
dc.subjectInfancyen_US
dc.subjectLocien_US
dc.subjectAgeen_US
dc.titleGenetic and environmental influences on adult human height across birth cohorts from 1886 to 1994en_US
dc.typeArticleen_US

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