Yazar "Arslantas, Ali" seçeneğine göre listele

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    A Comparative Study on DNA Binding Properties of 2,10,16,24-Tetrakis 4-(4-hydroxyphenyl)-1-phenylethyl) phenoxy)-Substituted Co(II) and Mg(II) Phthalocyanine Compounds
    (Wiley-V C H Verlag Gmbh, 2017) Arslantas, Ali; Agirtas, Mehmet Salih
    In this study, DNA binding properties of 2,10,16,24-tetrakis4-(4-hydroxyphenyl)-1-phenylethyl)phenoxy)phthalocyaninato Co(II) and Mg(II) compounds were analyzed. CT-DNA was used to determine DNA binding properties of Co(II) (4) and Mg(II) (5) phthalocyanine compounds. The DNA binding properties of compounds 4 and 5 were investigated using electronic absorption titration, fluorescence spectroscopy, cyclic voltammetry, thermal denaturation study, electrophoresis and viscosity measurements in Tris-buffer (pH 7.0). The results indicated that Co(II) and Mg(II) phthalocyanine compounds have strong affinity for CT-DNA through intercalation.
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    DNA binding studies of the 2,10,16,24-tetrakis (phenoxy-3-methoxybenzoic acid)phthalocyaninato) Co(II) and Cu(II) compounds
    (Springer Int Publ Ag, 2020) Balli, Zekeriya; Arslantas, Ali; Solgun, Derya Gungordu; Agirtas, Mehmet Salih
    Tetra phenoxy-3-methoxybenzoic acid substituted Co(II) and Cu(II) metal phthalocyanine compounds were reported for the first time. The structures of these compounds were elucidated by NMR, FT-IR, UV-vis spectroscopy, and elemental analysis. The UV/Vis, fluorescence spectra, viscosity and the thermal melting point techniques were implemented to analyze the DNA bonding activities of cobalt (II) and copper (II) complexes of phthalocyanine by calf thymus DNA. These techniques showed that the phthalocyanine complexes interacted with the DNA molecule through the intercalation mechanism. Additionally, among the methods above, the binding properties of DNA with the compounds 4 and 5 were studied by means of the agarose gel electrophoresis method. The complexes 4 and 5 bonded to the DNA molecule in the buffer system at a pH of 7.02. The findings of these methods proved that the Co(II) and Cu(II) complexes of phthalocyanine could be evaluated as potential cancer medicine for cancer treatment in the near future.
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    The interaction between a zinc(II) phthalocyanine compound bearing octakis phenoxyacetamide substituents and calf thymus DNA
    (Tubitak Scientific & Technological Research Council Turkey, 2018) Arslantas, Ali; Agirtas, Mehmet Salih
    In this study, a zinc(II) phthalocyanine compound (PcZn) substituted with octakis phenoxyacetamide was synthesized and characterized. Calf thymus DNA (CT-DNA) was used to determine the DNA binding properties of the zinc(II) phthalocyanine compound. This interaction of CT-DNA with PcZn was investigated using electronic absorption spectra, emission spectroscopy, a thermal melting temperature study, cyclic voltammetry, and viscosity measurements in a Tris-HCl buffer solution at a pH of 7.2. The findings showed that zinc(II) phthalocyanine interacts with calf thymus DNA via partial intercalative binding mechanisms. In addition to the techniques above, a gel electrophoresis study was also carried out to verify the interaction of CT-DNA with the PcZn complex. The results demonstrated that the octakis phenoxyacetamide-substituted zinc(II) phthalocyanine complex binds to CT-DNA via a partial intercalative binding mode.
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    Investigation of DNA Binding Activities of Peripherally 2,10,16,24-Tetrakis Dimethyl 5-(Phenoxy)-Isophthalate-Substituted Ni(II) Phthalocyanine Complex
    (Wiley-V C H Verlag Gmbh, 2018) Arslantas, Ali; Agirtas, Mehmet Salih
    Peripherally 2, 10, 16, 24-tetrakis dimethyl 5-(phenoxy)-isophthalate-substituted Ni(II) phthalocyanine compound (Pc7) was previously synthesized and characterized. In this work, calf thymus DNA was used to specify DNA binding activities of Ni(II) phthalocyanine compound. DNA binding properties of Pc7 were studied using absorption titration, fluorescense spectroscopy, thermal melting temperature study, cyclic voltametry in a Tris-HCl buffer solution. The results indicated that Pc7 can bind to CT-DNA molecule through partial intercalation binding mechanisms. In addition to above methods, agarose gel electrophoresis and viscosity measurement were also conducted to confirm DNA binding activities activities of Pc7. The results of these methods indicated that Ni(II) phthalocyanine compound adheres to CT-DNA partial intercalative binding mode. These results confirm that Ni(II) phthalocyanine compound may become potential therapeutic agent for cancerous cells due to its DNA binding features.
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    INVESTIGATION OF DNA BINDING AND CLEAVAGE ACTIVITIES OF BORON COMPLEXES IN THE PRESENCE OF HYDROGEN PEROXIDE
    (Univ Babes-Bolyai, 2014) Devrim, Alparslan Kadir; Arslantas, Ali; Sudagidan, Mert; Kose, Dursun Ali; Karan, Birgul
    Magnesium [di(hydroxy)mono(citratoborate)]dihydrate (Mg[B(Cit)(OH)(2)](2)center dot 2H2O), Lithium [di(hydroxy)mono(citratoborate)]hydrate Li[B(Cit)(OH)(2)]center dot H2O, Sodium [di(hydroxy)mono(salicylato) borate)hydrate Na[B(Sal)(OH)(2)]center dot H2O and Magnesium[bis(salicylatoborate)]decahydrate Mg[B(Sal)(2)](2)center dot 10H(2)O) complexes have been synthesized and characterized. The cattle genomic DNA (CG-DNA) interaction of the complexes was studied by spectroscopic methods, viscosity, and electrophoresis measurements. The complexes partially intercalated to CG-DNA. Furthermore, DNA cleavage activity of these complexes was also investigated using agarose gel electrophoresis and the complexes show moderate ability of cleavage to the DNA.
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    Investigation of DNA-Binding Activities of Zinc(II) and Cobalt(II) Phthalocyanine Compounds with 3,4,5-Trimethoxybenzyloxy Substituents
    (Wiley-V C H Verlag Gmbh, 2017) Arslantas, Ali; Agirtas, Mehmet Salih
    In this study, DNA-binding activities of previously synthesized tetrakis(3,4,5-trimethoxybenzyloxy)-substituted Zn(II) and Co(II) phthalocyanines (Pc4 and Pc5) have been chosen for the study. The interaction of synthesized tetrakis(3,4,5-trimethoxybenzyloxy)-substituted Zn(II) and Co(II) phthalocyanine compounds with CT-DNA was investigated by using UV/Vis titrimetric method, fluorescence spectroscopy, cyclic voltammetry, thermal denaturation profile, gel electrophoresis and viscosty measurement in a Tris-HCI buffer at pH 7.0. The results indicated that tetrakis(3,4,5-trimethoxybenzyloxy)-substituted Zn(II) and Co(II) phthalocyanines (Pc4 and Pc5) can interact with CT-DNA via intercalation binding mode.
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    Studies on DNA Interaction with 2(3),9(10), 16(17), 23(24)-Tetrakis 2((4-Phenoxyphenyl) Diazeylbenzoic acid)phthalocyaninato Zinc (II) Compound
    (Wiley-V C H Verlag Gmbh, 2018) Arslantas, Ali; Agirtas, Mehmet Salih
    In this study, 2(3), 9(10), 16(17), 23(24)-tetrakis 2((4-phenoxyphenyl) diazeylbenzoic acid)phthalocyaninato zinc (II) compound was chosen to study DNA binding activities. The binding activities of zinc (II) phthalocyanine compound bearing 2(3),9(10), 16(17), 23(24)-tetrakis 2((4-Phenoxyphenyl) diazeylbenzoic acid) ligand with Calf Thymus (CT)-DNA was investigated using absorption titration, fluorescence spectroscopy, cyclic voltammetry and thermal melting profile in a Tris-HCl buffer system at pH7.0. In addition to these methods, gel electrophoresis and viscosity measurements were also carried out to determine DNA binding activities with compound 6 in a buffer solution. The results indicated that compound 6 interacts with CT-DNA through partial intercalation binding mode.
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    Synthesis, Aggregation, Antioxidant and DNA-Binding Properties of Metallophthalocyanines Bearing 5-Tert-butyl-2-hydroxyphenoxy Groups
    (Wiley-V C H Verlag Gmbh, 2017) Agirtas, Mehmet Salih; Cabir, Beyza; Ozdemir, Sadin; Okumus, Veysi; Arslantas, Ali
    In this study, the synthesis and characterization of new substituted metallophthalocyanines are described. A new phthalonitrile, 4-(5-tert-butyl-2-hydroxyphenoxy)-5-chlorophthalonitrile (3) was prepared. New compounds were characterized by UV-Vis, IR, H-1 NMR, and elemental analysis. The aggregation behavior of the cobalt (II), magnesium (II) and copper (II) phthalocyanines were studied in tetrahydrofuran and in known concentration ranges. The antioxidant activities of compounds were evaluated. Their radical-scavenging capacity, metal chelating activity and reducing power was fully studied. The compound 3 showed 100% chelating activity as EDTA at concentration 50 mg/L. The DNA interaction of copper (II) phthalocyanine compound (6) was studied using UV/Vis titration, gel electrophoresis, cyclic voltammetry. The results indicated that compound 6 interacts with CT-DNA via intercalation binding mode.